Rabbit Polyclonal HIRA(N-term) Antibody

The HIRA (Histone Cell Cycle Regulation Defective Homolog A) protein is a critical chaperone involved in histone deposition and chromatin remodeling, particularly for the replication-independent incorporation of the histone variant H3.3 into chromatin. It functions as part of the HUCA complex (HIRA, UBN1. and CABIN1) and plays roles in transcriptional regulation, DNA repair, and cellular differentiation. The N-terminal region of HIRA is essential for its interactions with partner proteins and its recruitment to specific genomic loci. Antibodies targeting the N-terminus of HIRA (HIRA N-term antibodies) are valuable tools for studying its localization, protein-protein interactions, and regulatory mechanisms in diverse biological contexts. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate HIRA's involvement in developmental processes, cellular senescence, and diseases such as cancer or neurodevelopmental disorders. Research has highlighted HIRA's role in maintaining genome stability and epigenetic memory, with its dysregulation linked to developmental defects and oncogenesis. The development and validation of HIRA N-term antibodies have enabled deeper exploration of how HIRA-mediated H3.3 deposition influences chromatin dynamics, gene expression, and disease pathways.