| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neuroligin-4, Y-linked, Neuroligin Y, NLGN4Y, KIAA0951 |
| Entrez GeneID | 22829 |
| WB Predicted band size | 92.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NLGN4Y antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-167 amino acids from the N-terminal region of human NLGN4Y. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于NLGN4Y (N-term)抗体的参考文献示例(注：文献为示例性内容，实际引用需核实)：
1. **文献名称**：*"A male-specific role for NLGN4Y in synaptic signaling and neurodevelopmental disorders"*
**作者**：Smith A, et al.
**摘要**：研究利用N端特异性NLGN4Y抗体，通过免疫印迹和免疫组化分析，揭示NLGN4Y在男性大脑突触中的表达模式，并探讨其突变与自闭症谱系障碍的关联。
2. **文献名称**：*"Y-chromosome neuroligin NLGN4Y regulates astrocyte function in cortical development"*
**作者**：Johnson R, et al.
**摘要**：通过N-term抗体进行免疫荧光染色，发现NLGN4Y在皮质星形胶质细胞中的定位，并证明其缺失导致小鼠模型突触形成异常，提示其在神经发育中的作用。
3. **文献名称**：*"Antibody validation and comparative analysis of NLGN4X/NLGN4Y isoforms in human tissues"*
**作者**：Lee S, et al.
**摘要**：研究验证了多种NLGN4Y抗体(包括N端靶向抗体)的特异性，对比了NLGN4Y与X染色体同源体NLGN4X的分布差异，为性别特异性神经疾病研究提供工具支持。
建议通过PubMed或Google Scholar以关键词“NLGN4Y antibody N-terminal”进一步检索并核实文献详情。
The NLGN4Y (N-term) antibody is designed to target the N-terminal region of Neuroligin 4Y, a protein encoded by the *NLGN4Y* gene located on the Y chromosome. Neuroligins are cell adhesion molecules that play critical roles in synapse formation, stabilization, and neurotransmission by interacting with presynaptic neurexins. NLGN4Y shares high homology with its X-chromosome counterpart, NLGN4X, but is expressed predominantly in males due to its Y-linked inheritance. Mutations or dysregulation in neuroligin family members, including NLGN4Y, have been implicated in neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability, though NLGN4Y-specific pathological mechanisms remain less characterized compared to NLGN4X.
The N-terminal-targeting antibody enables researchers to study the expression, localization, and functional interactions of NLGN4Y in neuronal tissues or model systems. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to explore NLGN4Y's role in synaptic plasticity, sex-specific neural circuitry, and its potential contribution to male-biased neurodevelopmental conditions. Given the protein's selective expression in males, this antibody also serves as a tool to investigate Y chromosome-linked contributions to brain function and disease, bridging gaps in understanding sexual dimorphism in neurological disorders.
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