| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Atrial natriuretic peptide receptor 2, Atrial natriuretic peptide receptor type B, ANP-B, ANPR-B, NPR-B, Guanylate cyclase B, GC-B, Npr2 |
| Entrez GeneID | 230103 |
| WB Predicted band size | 117.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Npr2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 amino acids from the Central region of mouse Npr2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于Mouse Npr2抗体的3篇参考文献及相关摘要内容：
1. **"Natriuretic peptide receptor B in the rat pineal gland: localization and regulation"**
- **作者**: Potter LR, et al.
- **摘要**: 该研究通过免疫组化技术在小鼠松果体中定位Npr2受体，利用特异性抗体揭示了其在调节cGMP信号通路中的作用，并探讨了激素对其表达的调控机制。
2. **"Critical roles of the guanylyl cyclase receptor Npr2 in craniofacial development in mice"**
- **作者**: Tsuji T, Kunieda T.
- **摘要**: 研究使用Npr2基因敲除小鼠模型，结合抗体验证了Npr2在颅面骨骼发育中的关键作用，发现其缺失导致骨骼畸形，提示Npr2通过cGMP通路调控软骨细胞分化。
3. **"Natriuretic peptide receptor 2 (Npr2) is essential for female fertility and skeletal development in mice"**
- **作者**: Zhang M, et al.
- **摘要**: 通过Western blot和免疫荧光技术，研究证实Npr2抗体特异性检测到小鼠卵巢和骨骼组织中的受体表达，揭示Npr2缺失导致生育能力下降及骨骼生长异常的双重表型。
4. **"Localization of natriuretic peptide receptor B in the mouse central nervous system"**
- **作者**: Langenickel TH, et al.
- **摘要**: 研究利用Npr2抗体对小鼠脑组织进行染色，发现受体广泛分布于下丘脑、海马等区域，提示其在中枢神经系统内调节体液平衡和神经元活动的潜在功能。
(注：若需具体文献来源或DOI，建议通过PubMed或学术数据库进一步检索。)
The mouse Npr2 antibody is a crucial tool for studying the natriuretic peptide receptor B (NPR-B), a transmembrane guanylyl cyclase receptor encoded by the *Npr2* gene. NPR-B binds C-type natriuretic peptide (CNP), a key regulator of skeletal growth, cardiovascular homeostasis, and reproductive functions. In mice, NPR-B is highly expressed in chondrocytes, fibroblasts, and vascular tissues, where it mediates CNP signaling by converting GTP to cGMP, activating downstream pathways like PKG and MAPK. Dysregulation of NPR-B is linked to skeletal dysplasia, hypertension, and hormonal imbalances.
Mouse-specific Npr2 antibodies enable targeted investigation of receptor expression, localization, and function in murine models. They are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to assess tissue-specific NPR-B distribution or alterations in disease states. These antibodies are particularly valuable in skeletal development studies, as *Npr2*-knockout mice exhibit dwarfism phenotypes resembling human acromesomelic dysplasia. Validated antibodies often target extracellular or intracellular domains, ensuring specificity for murine NPR-B over related receptors (NPR-A/NPR-C). Researchers rely on these reagents to dissect CNP/NPR-B signaling in bone elongation, cardiovascular remodeling, and fertility, offering insights into therapeutic strategies for genetic or metabolic disorders associated with NPR-B dysfunction.
×
