| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Metal transporter CNNM2, Ancient conserved domain-containing protein 2, Cyclin-M2, CNNM2, ACDP2 |
| Entrez GeneID | 54805 |
| WB Predicted band size | 96.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CNNM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 646-674 amino acids from the C-terminal region of human CNNM2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CNNM2抗体的3篇文献示例(注：文献信息为示例，非真实存在，仅供格式参考)：
1. **文献名称**：*CNNM2 regulates magnesium homeostasis and modulates tumor progression in colorectal cancer*
**作者**：Zhang Y, et al.
**摘要**：本研究利用CNNM2特异性抗体分析结直肠癌组织中CNNM2蛋白表达，发现其过表达与肿瘤转移和患者预后不良相关，机制可能与镁离子依赖性信号通路异常激活有关。
2. **文献名称**：*Structural and functional characterization of CNNM2 as a magnesium transporter*
**作者**：De Baaij JHF, et al.
**摘要**：通过免疫印迹和免疫荧光技术(使用抗CNNM2抗体)，揭示了CNNM2在细胞膜上的定位及其在镁离子跨膜转运中的关键作用，并发现突变会导致遗传性低镁血症。
3. **文献名称**：*CNNM2 variants impair synaptic plasticity and contribute to neurodevelopmental disorders*
**作者**：Nishizawa Y, et al.
**摘要**：在小鼠模型中，通过CNNM2抗体检测发现其海马区表达异常，表明CNNM2缺失导致突触可塑性受损，可能与自闭症谱系障碍的病理机制相关。
(注：实际文献需通过PubMed或Google Scholar检索关键词“CNNM2 antibody”或“CNNM2 function”获取。)
The CNNM2 antibody is a research tool designed to detect and study CNNM2 (Cyclin and CBS domain divalent metal cation transport mediator 2), a protein involved in cellular magnesium homeostasis. CNNM2. part of the CNNM family, plays a critical role in magnesium transport and regulation, essential for numerous physiological processes, including ATP metabolism, DNA stability, and enzyme function. Structurally, it contains conserved cyclic nucleotide-binding homology (CNBH) and CBS (cystathionine beta-synthase) domains, which are implicated in metal ion binding and transport. Dysregulation of CNNM2 has been linked to hypomagnesemia, kidney disorders, and cancers, making it a target for studying metabolic and oncogenic pathways.
The CNNM2 antibody is widely used in Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions in tissues or cell lines. Research highlights its role in magnesium-dependent signaling pathways, such as the PRL-CNNM2 complex, which regulates cellular Mg²⁺ efflux. Studies also suggest CNNM2's involvement in tumor progression, particularly in glioblastoma and breast cancer, where altered Mg²⁺ dynamics may influence cell proliferation and metastasis. Additionally, genetic variants in CNNM2 are associated with inherited hypomagnesemia, emphasizing its clinical relevance. The antibody thus serves as a vital reagent for exploring magnesium homeostasis mechanisms and their implications in disease pathophysiology.
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