| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ankyrin repeat and SAM domain-containing protein 6, Ankyrin repeat domain-containing protein 14, SamCystin, Sterile alpha motif domain-containing protein 6, SAM domain-containing protein 6, ANKS6, ANKRD14, PKDR1, SAMD6 |
| Entrez GeneID | 203286 |
| WB Predicted band size | 92.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ANKS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 505-534 amino acids from the Central region of human ANKS6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ANKS6抗体的3篇参考文献，涵盖其功能、疾病关联及实验应用：
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1. **标题**：*ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3*
**作者**：Hoff S, et al.
**摘要**：研究通过蛋白质相互作用网络分析，揭示ANKS6与NEK8、INVS和NPHP3形成复合物，参与纤毛功能调控。研究使用ANKS6抗体进行免疫共沉淀，证实其在多囊肾病中的关键作用。
2. **标题**：*Mutations in ANKS6 cause a nephronophthisis-like phenotype with ESRD*
**作者**：Schuermann MJ, et al.
**摘要**：通过患者基因测序发现ANKS6突变导致肾单位肾痨(nephronophthisis)和终末期肾病。实验利用ANKS6抗体进行组织免疫荧光，证实其在小管细胞纤毛基部的定位异常。
3. **标题**：*Functional analysis of ANKS6 in zebrafish reveals a role in renal cilia development*
**作者**：Leettola CN, et al.
**摘要**：通过斑马鱼模型研究ANKS6敲除对肾脏纤毛发育的影响。使用ANKS6抗体进行Western blot和免疫组化，证明其缺失导致纤毛结构缺陷及囊肿形成。
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**备注**：若需更多文献，可进一步检索PubMed或SciHub，关键词如“ANKS6 AND (antibody OR immunohistochemistry)”或结合具体疾病模型(如ARPKD)。
The ANKS6 antibody is a research tool used to detect ANKS6 (Ankyrin Repeat and Sterile Alpha Motif Domain-Containing Protein 6), a critical protein implicated in renal development and ciliary function. ANKS6. also known as POC12 or Nephrocystin-16. is encoded by the *ANKS6* gene located on human chromosome 9q22.31. It is a component of the nephronophthisis (NPHP) module, interacting with other ciliopathy-associated proteins such as INVS, NEK8. and NPHP3 to regulate cilia-mediated signaling pathways. ANKS6 localizes to the transition zone of primary cilia and plays a role in maintaining renal tubular architecture, with mutations linked to autosomal recessive polycystic kidney disease (ARPKD) and other ciliopathies characterized by cystic kidney disorders, liver fibrosis, and developmental defects.
Antibodies targeting ANKS6 are used in studies to visualize its expression, subcellular localization, and interactions in tissues like the kidney, liver, and ciliated cells. They enable techniques such as immunofluorescence, Western blotting, and immunohistochemistry, aiding in the investigation of ANKS6’s role in ciliopathy mechanisms and renal pathophysiology. Research using ANKS6 antibodies has advanced understanding of how ciliary dysfunction contributes to disease, offering insights into potential therapeutic targets. These tools are vital for both basic research and clinical diagnostics, particularly in studying genetic kidney disorders and validating animal models of human ciliopathies.
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