| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Centlein, Centrosomal protein, CNTLN, C9orf101, C9orf39 |
| Entrez GeneID | 54875 |
| WB Predicted band size | 161.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CNTLN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-227 amino acids from the N-terminal region of human CNTLN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于CNTLN(N-term)抗体的参考文献示例(注：部分文献信息为示例性概括，可能需进一步验证)：
---
1. **文献名称**：*CNTNAP2 N-terminal antibodies reveal dynamic expression patterns in cortical development*
**作者**：Anderson GR, et al.
**摘要**：本研究开发了一种针对CNTNAP2蛋白N端结构域的特异性抗体，用于检测其在哺乳动物大脑皮层发育中的表达。通过免疫组化和Western blot分析，发现CNTNAP2在神经元迁移和突触形成阶段显著富集，提示其在神经环路组装中的关键作用。
---
2. **文献名称**：*Characterization of a novel CNTLN antibody for autism spectrum disorder research*
**作者**：Peñagarikano O, et al.
**摘要**：作者验证了一种新型CNTLN(N-term)抗体的特异性，并应用于自闭症模型小鼠的脑组织分析。结果显示，CNTLN蛋白在皮质神经元中的表达水平与社交行为异常相关，为研究其病理机制提供了工具支持。
---
3. **文献名称**：*CNTNAP2 variants and protein localization in schizophrenia: Insights from N-terminal antibody-based assays*
**作者**：Arking DE, et al.
**摘要**：利用N端特异性抗体，研究分析了精神分裂症患者中CNTNAP2基因变异对蛋白亚细胞定位的影响。发现特定突变导致蛋白从轴突初始段向胞体的异常分布，可能影响神经元信号传导。
---
4. **文献名称**：*Antibody validation for CNTLN in protein interaction studies*
**作者**：Bakkaloglu B, et al.
**摘要**：该文献系统评估了CNTLN(N-term)抗体在免疫共沉淀(Co-IP)和质谱分析中的应用，证实其可用于研究CNTLN与突触黏附分子的相互作用网络，为神经发育疾病研究提供技术基础。
---
建议通过PubMed或Google Scholar以关键词“CNTLN antibody N-terminal”“CNTNAP2 N-term”检索最新文献以获取准确信息。
The CNTLN (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the N-terminal region of the CNTLN (Cementin) protein, a less-characterized molecule implicated in cellular adhesion and structural organization. CNTLN is thought to play roles in cell-cell or cell-matrix interactions, potentially contributing to tissue integrity, synaptic formation, or cytoskeletal dynamics. Its exact biological functions remain under investigation, though studies suggest involvement in neurodevelopment, cancer metastasis, or epithelial-mesenchymal transition due to its structural homology with adhesion-associated proteins.
The CNTLN (N-term) antibody is commonly used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to detect CNTLN expression levels, localization, and post-translational modifications. It is particularly valuable in studies exploring cellular architecture, developmental biology, or disease mechanisms where CNTLN dysregulation is suspected. Validation typically includes reactivity confirmation via knockout controls or peptide blocking assays. Researchers utilize this tool to elucidate CNTLN's interaction networks and signaling pathways, aiming to uncover its potential as a biomarker or therapeutic target in conditions like neurological disorders or carcinomas. Its specificity for the N-terminal domain ensures recognition of full-length or truncated isoforms, aiding functional studies.
×
