| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAGUK p55 subfamily member 3, Discs large homolog 3, Protein MPP3, MPP3, DLG3 |
| Entrez GeneID | 4356 |
| WB Predicted band size | 66.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MPP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406-434 amino acids from the C-terminal region of human MPP3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MPP3抗体的3篇参考文献示例(内容为虚构，仅作格式参考)：
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1. **文献名称**：*MPP3 regulates epithelial cell polarity via scaffolding interactions with Par3 and aPKC*
**作者**：Smith J, et al.
**摘要**：本研究通过免疫共沉淀和免疫荧光技术，利用MPP3特异性抗体揭示了其在维持上皮细胞极性中的关键作用。结果表明，MPP3与Par3/aPKC复合物相互作用，抗体敲除实验显示细胞极性丧失，提示其作为支架蛋白的功能。
2. **文献名称**：*Antibody-based profiling of MPP3 expression in colorectal cancer progression*
**作者**：Chen L, et al.
**摘要**：通过开发高特异性MPP3单克隆抗体，作者在结直肠癌组织微阵列中分析了MPP3蛋白表达水平。结果显示，MPP3在晚期肿瘤中显著下调，且与患者生存率正相关，提示其潜在抑癌作用。
3. **文献名称**：*MPP3 antibody reveals synaptic localization in murine hippocampal neurons*
**作者**：Garcia R, et al.
**摘要**：利用兔源MPP3多克隆抗体进行免疫电镜分析，首次证实MPP3蛋白富集于小鼠海马神经元突触后膜。功能研究表明，MPP3缺失导致突触可塑性异常，提示其在神经信号传导中的新角色。
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注：以上文献为示例，实际引用需根据真实研究调整。建议通过PubMed或Google Scholar以“MPP3 antibody”或“MPP3 protein function”为关键词检索最新文献。
MPP3 (Membrane Palmitoylated Protein 3), also known as MAGUK p55 subfamily member 3. is a scaffolding protein belonging to the membrane-associated guanylate kinase (MAGUK) family. It plays a critical role in maintaining cell polarity, synaptic organization, and signal transduction by facilitating protein-protein interactions at specialized membrane domains, such as tight junctions in epithelial cells or postsynaptic densities in neurons. MPP3 contains characteristic PDZ, SH3. and guanylate kinase (GUK) domains, enabling it to assemble multiprotein complexes involved in cellular adhesion, trafficking, and signaling pathways like the Hippo pathway.
Antibodies targeting MPP3 are essential tools for investigating its expression, localization, and functional interactions in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study MPP3's role in tissue development, epithelial barrier integrity, and neurological function. Dysregulation of MPP3 has been implicated in cancers, neurodevelopmental disorders, and epithelial dysfunction, making these antibodies valuable for diagnostic or therapeutic research. Commercial MPP3 antibodies are typically raised against specific epitopes, often within conserved regions like the PDZ domain, and validated for species cross-reactivity (e.g., human, mouse, rat). Recent studies also utilize recombinant antibodies or CRISPR-based tagging to explore dynamic interactions with binding partners like DLG1 or CASK, enhancing understanding of MPP3's regulatory networks.
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