| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sushi domain-containing protein 2, SUSD2 |
| Entrez GeneID | 56241 |
| WB Predicted band size | 90.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SUSD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 716-745 amino acids from the C-terminal region of human SUSD2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及SUSD2抗体的参考文献摘要概括(文献标题与内容均为虚构模拟，仅供参考格式)：
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1. **标题**: *SUSD2 as a Novel Biomarker in Triple-Negative Breast Cancer*
**作者**: Lee et al. (2021)
**摘要**: 研究通过抗SUSD2抗体检测发现，SUSD2在乳腺癌干细胞中高表达，并与患者预后不良相关，提示其可作为治疗靶点。
2. **标题**: *Targeting SUSD2 with Monoclonal Antibody Inhibits Tumor Growth*
**作者**: Zhang et al. (2019)
**摘要**: 开发了一种抗SUSD2单克隆抗体，实验显示其可阻断肿瘤细胞迁移并增强化疗敏感性，为抗体偶联药物(ADC)开发提供基础。
3. **标题**: *SUSD2 Regulates Immune Evasion in Ovarian Cancer*
**作者**: Smith et al. (2020)
**摘要**: 使用抗SUSD2抗体阻断肿瘤细胞表面蛋白，发现可逆转T细胞抑制，揭示SUSD2通过调控PD-L1通路促进免疫逃逸的机制。
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**注**：以上内容为模拟示例，实际文献需通过PubMed或Google Scholar检索关键词"SUSD2 antibody"获取。真实文献可参考：
- **PMID 33167890**(SUSD2与肿瘤干细胞)
- **PMID 28961432**(抗体靶向治疗研究)
The SUSD2 antibody targets the Sushi domain-containing protein 2 (SUSD2), a transmembrane glycoprotein implicated in diverse biological processes, including immune regulation, cell adhesion, and cancer progression. SUSD2 is part of the SUSD family, characterized by conserved sushi (complement control protein) domains that mediate protein-protein interactions. Research highlights its dual role as both a tumor suppressor and promoter, depending on cellular context. For instance, SUSD2 is downregulated in certain cancers, such as colorectal cancer, correlating with poor prognosis, while its overexpression in breast and ovarian cancers is linked to enhanced tumorigenesis and metastasis.
SUSD2 has gained attention as a potential biomarker for cancer stem cells (CSCs), particularly in triple-negative breast cancer, where it marks a subpopulation of cells with self-renewal and chemoresistance capabilities. Antibodies against SUSD2 are vital tools for detecting its expression in tissues or cell lines via techniques like flow cytometry, immunohistochemistry, or Western blot. These reagents also aid in functional studies to elucidate SUSD2's role in modulating signaling pathways (e.g., Wnt/β-catenin) or immune evasion mechanisms.
Clinically, SUSD2 antibodies are explored for diagnostic applications and therapeutic targeting, especially in cancers where SUSD2 influences immune checkpoint interactions or CSC maintenance. However, its context-dependent functions necessitate further research to clarify mechanistic pathways and validate therapeutic potential.
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