关键信息
-
基因名
Cacng1
- 应用
-
别名
(Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma)
-
种属
Mouse
-
表达系统
E. coli
-
标签
N- His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O70578
-
表达区间
1-223aa
-
分子量
26.6 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Cacng1, also known as the calcium channel voltage-dependent gamma 1 subunit, plays a crucial role in the modulation of calcium channels in excitable tissues, such as neurons and muscle cells. This subunit is essential in the formation and functioning of voltage-gated calcium channels (VGCCs), which are pivotal for various physiological processes, including neurotransmitter release, muscle contraction, and gene expression regulation. Abnormalities in Cacng1 expression or function have been implicated in several neurological disorders and cardiovascular diseases, underscoring its potential as a therapeutic target. Recent studies have focused on the recombinant production of Cacng1 to better understand its structure and function at a molecular level. By utilizing recombinant DNA technology, researchers can produce purified Cacng1 proteins for functional assays, binding studies, and structural analyses. These investigations aim to elucidate the mechanisms through which Cacng1 influences calcium channel activity and to explore how alterations in its function can lead to pathological states. Ultimately, enhanced knowledge of Cacng1's biology could pave the way for novel treatments for diseases associated with calcium signaling dysregulation.
