Rabbit Polyclonal CTTNBP2NL(N-term) Antibody

The CTTNBP2NL (N-term) antibody is designed to target the N-terminal region of the CTTNBP2NL protein (Cortactin Binding Protein 2 N-Terminal Like), a less-characterized member of the cortactin-binding protein family. CTTNBP2NL shares structural homology with CTTNBP2. which interacts with cortactin—a key regulator of actin cytoskeleton dynamics involved in cell migration, adhesion, and synaptic plasticity. While CTTNBP2 is implicated in neuronal development and dendritic spine formation, CTTNBP2NL’s precise biological role remains unclear, though it is thought to participate in similar cellular processes, potentially modulating cortactin-dependent pathways. The N-terminal region of CTTNBP2NL likely contains critical functional domains for protein-protein interactions or subcellular localization. Researchers use this antibody primarily in techniques like Western blotting, immunofluorescence, or immunohistochemistry to investigate CTTNBP2NL expression, localization, and interactions in cellular or tissue models. Its application aids in exploring the protein’s involvement in neurological disorders, cancer (given cortactin’s role in metastasis), or developmental processes. Validation data, such as reactivity in knockout controls or peptide-blocking assays, are essential to confirm specificity, as cross-reactivity with homologous proteins (e.g., CTTNBP2) could complicate interpretations. Overall, this antibody serves as a tool to unravel the understudied functions of CTTNBP2NL in health and disease.