Rabbit Polyclonal VWA2(N-term) Antibody

The VWA2 (N-term) antibody is designed to target the N-terminal region of the von Willebrand factor A domain-containing protein 2 (VWA2), also known as COBL-like 1. VWA2 is an extracellular matrix-associated protein implicated in cell adhesion, migration, and signaling. It contains a von Willebrand type A (VWA) domain, a conserved motif involved in protein-protein interactions, often linked to integrin binding or extracellular matrix organization. VWA2 is expressed in various tissues, including the nervous system, kidneys, and reproductive organs, and has been studied in contexts such as cancer, neural development, and tissue remodeling. Dysregulation of VWA2 is associated with tumor progression, metastasis, and poor prognosis in certain cancers, possibly due to its role in modulating cell-matrix communication. The VWA2 (N-term) antibody, typically developed in rabbit or mouse hosts, is used in applications like Western blotting, immunohistochemistry, and immunofluorescence to detect endogenous VWA2 protein levels. Its specificity for the N-terminal region ensures recognition of full-length or truncated isoforms, aiding research into VWA2’s functional domains, post-translational modifications, and interactions with ligands like integrins or growth factors. This antibody serves as a critical tool for exploring VWA2’s biological roles and potential therapeutic relevance.