| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Guanine nucleotide-binding protein G(t) subunit alpha-2, Transducin alpha-2 chain, GNAT2, GNATC |
| Entrez GeneID | 2780 |
| WB Predicted band size | 40.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This GNAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-169 amino acids from the Central region of human GNAT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GNAT2抗体的3篇文献摘要简述：
1. **文献名称**: "Immunolocalization of cone transducin subunits in the mammalian retina"
**作者**: Peng YW, et al.
**摘要**: 该研究利用GNAT2特异性抗体，揭示了GNAT2蛋白在哺乳动物视网膜视锥细胞中的选择性表达，证实其在光转导信号通路中的核心作用，并对比了不同物种间的表达差异。
2. **文献名称**: "Mutations in GNAT2 associated with achromatopsia affect antibody recognition in structural studies"
**作者**: Kohl S, et al.
**摘要**: 通过GNAT2抗体对色盲症患者突变蛋白进行免疫印迹分析，发现特定突变位点导致抗体结合能力改变，为疾病分子机制提供了实验依据。
3. **文献名称**: "Proteomic profiling of photoreceptor outer segments using GNAT2-specific antibodies"
**作者**: Lobanova ES, et al.
**摘要**: 研究采用GNAT2抗体富集视锥细胞外段蛋白，建立了高分辨率蛋白质组图谱，发现GNAT2与其他光转导蛋白的相互作用网络，推进了对视觉信号复合体的理解。
注：以上文献信息为示例性内容，实际文献需通过PubMed或Web of Science等数据库验证。建议结合具体研究需求补充近年研究(如2020年后关于GNAT2结构解析或疾病模型的文献)。
The GNAT2 antibody is a specialized tool used to detect and study the GNAT2 protein, a critical component in the phototransduction cascade within cone photoreceptor cells of the retina. GNAT2 (guanine nucleotide-binding protein G(t) subunit alpha-2) is a member of the transducin alpha-subunit family, functioning as a G-protein that couples with photopigments to convert light signals into cellular responses. It plays a vital role in color vision and visual acuity under daylight conditions.
Research involving GNAT2 antibodies focuses on understanding cone cell biology, inherited retinal disorders, and mechanisms underlying vision loss. Mutations in the GNAT2 gene are linked to autosomal recessive congenital achromatopsia (complete color blindness) and other cone dystrophies. The antibody enables visualization, quantification, and localization of GNAT2 expression in retinal tissues, aiding in the diagnosis of genetic eye diseases and the evaluation of experimental therapies, such as gene editing or retinal cell replacement.
GNAT2 antibodies are typically produced in host species (e.g., rabbits or mice) using immunogenic peptide sequences unique to the GNAT2 protein. They are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Their specificity and sensitivity make them indispensable in both basic research exploring phototransduction pathways and translational studies aiming to restore cone function in retinal degenerative conditions.
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