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Rabbit Polyclonal ZCCHC17 Antibody

  • 中文名: ZCCHC17抗体
  • 别    名: Nucleolar protein of 40 kDa, pNO40, Pnn-interacting nucleolar protein, Putative S1 RNA-binding domain protein, PS1D protein, Zinc finger CCHC domain-containing protein 17, ZCCHC17, PS1D
货号: IPDX33704
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNucleolar protein of 40 kDa, pNO40, Pnn-interacting nucleolar protein, Putative S1 RNA-binding domain protein, PS1D protein, Zinc finger CCHC domain-containing protein 17, ZCCHC17, PS1D
Entrez GeneID51538
WB Predicted band size27.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis ZCCHC17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-187 amino acids from the Central region of human ZCCHC17.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是几篇关于ZCCHC17抗体的假设性文献示例(实际文献需通过学术数据库查询):

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1. **文献名称**:*ZCCHC17 modulates RNA splicing and interacts with TDP-43 in neurodegenerative disease models*

**作者**:Smith A, et al. (2020)

**摘要**:研究利用ZCCHC17特异性抗体,发现其在RNA结合和剪接调控中的作用,并揭示其与TDP-43的相互作用,可能与肌萎缩侧索硬化症(ALS)的病理相关。

2. **文献名称**:*Altered expression of ZCCHC17 in Alzheimer’s disease brain correlates with Tau phosphorylation*

**作者**:Zhang L, et al. (2021)

**摘要**:通过免疫组化(IHC)和Western blot分析,发现ZCCHC17蛋白在阿尔茨海默病患者脑组织中表达下调,且与Tau蛋白异常磷酸化呈负相关。

3. **文献名称**:*ZCCHC17 regulates neuronal development via microRNA processing*

**作者**:Lee J, et al. (2019)

**摘要**:使用ZCCHC17抗体在小鼠模型中定位其亚细胞分布,提出ZCCHC17通过调控miRNA成熟影响神经元突触形成和发育。

4. **文献名称**:*A novel role of ZCCHC17 in promoting cancer metastasis through mRNA stability control*

**作者**:Chen X, et al. (2022)

**摘要**:通过免疫共沉淀(Co-IP)实验,发现ZCCHC17与肿瘤转移相关mRNA结合并增强其稳定性,抗体阻断实验表明其可能成为癌症治疗靶点。

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**说明**:以上为模拟文献,实际研究中建议通过PubMed、Google Scholar等平台以“ZCCHC17 antibody”或“ZCCHC17 function”为关键词检索,并筛选涉及该抗体应用的实验研究(如Western blot、IHC、IP等)。

背景信息

The ZCCHC17 antibody is a research tool designed to target the ZCCHC17 protein, a member of the zinc finger CCHC-type domain-containing protein family. ZCCHC17. also known as LARP7-like or PIDD-associated protein, is implicated in RNA binding and post-transcriptional regulation, potentially influencing RNA stability, splicing, or translation. Structurally, it contains conserved CCHC zinc finger motifs, which are critical for nucleic acid interactions. While its exact biological roles remain under investigation, ZCCHC17 has been linked to cellular stress responses, DNA damage repair pathways, and neuronal development. Dysregulation of ZCCHC17 expression has been observed in certain cancers and neurodegenerative disorders, suggesting its involvement in disease pathogenesis. The ZCCHC17 antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and interactions in cell lines or tissues. Validated antibodies enable researchers to explore ZCCHC17's molecular mechanisms, including its partnership with proteins like PIDD1 in apoptosis regulation or its role in RNA metabolism. Commercial availability of polyclonal or monoclonal variants facilitates diverse experimental applications, contributing to ongoing studies aimed at clarifying its physiological and pathological significance.

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