WB | 1/1000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 1/10-1/50 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | Nucleolar protein of 40 kDa, pNO40, Pnn-interacting nucleolar protein, Putative S1 RNA-binding domain protein, PS1D protein, Zinc finger CCHC domain-containing protein 17, ZCCHC17, PS1D |
Entrez GeneID | 51538 |
WB Predicted band size | 27.6kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | This ZCCHC17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-187 amino acids from the Central region of human ZCCHC17. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是几篇关于ZCCHC17抗体的假设性文献示例(实际文献需通过学术数据库查询):
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1. **文献名称**:*ZCCHC17 modulates RNA splicing and interacts with TDP-43 in neurodegenerative disease models*
**作者**:Smith A, et al. (2020)
**摘要**:研究利用ZCCHC17特异性抗体,发现其在RNA结合和剪接调控中的作用,并揭示其与TDP-43的相互作用,可能与肌萎缩侧索硬化症(ALS)的病理相关。
2. **文献名称**:*Altered expression of ZCCHC17 in Alzheimer’s disease brain correlates with Tau phosphorylation*
**作者**:Zhang L, et al. (2021)
**摘要**:通过免疫组化(IHC)和Western blot分析,发现ZCCHC17蛋白在阿尔茨海默病患者脑组织中表达下调,且与Tau蛋白异常磷酸化呈负相关。
3. **文献名称**:*ZCCHC17 regulates neuronal development via microRNA processing*
**作者**:Lee J, et al. (2019)
**摘要**:使用ZCCHC17抗体在小鼠模型中定位其亚细胞分布,提出ZCCHC17通过调控miRNA成熟影响神经元突触形成和发育。
4. **文献名称**:*A novel role of ZCCHC17 in promoting cancer metastasis through mRNA stability control*
**作者**:Chen X, et al. (2022)
**摘要**:通过免疫共沉淀(Co-IP)实验,发现ZCCHC17与肿瘤转移相关mRNA结合并增强其稳定性,抗体阻断实验表明其可能成为癌症治疗靶点。
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**说明**:以上为模拟文献,实际研究中建议通过PubMed、Google Scholar等平台以“ZCCHC17 antibody”或“ZCCHC17 function”为关键词检索,并筛选涉及该抗体应用的实验研究(如Western blot、IHC、IP等)。
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