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Rabbit Polyclonal GTSF1 Antibody

  • 中文名: GTSF1抗体
  • 别    名: Gametocyte-specific factor 1, Protein FAM112B, GTSF1, FAM112B
货号: IPDX33696
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGametocyte-specific factor 1, Protein FAM112B, GTSF1, FAM112B
Entrez GeneID121355
WB Predicted band size19.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis GTSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the Central region of human GTSF1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于GTSF1抗体的3篇参考文献及其简要摘要:

1. **文献名称**:*"GTSF1 is essential for piRNA biogenesis and retrotransposon silencing in mouse germline"*

**作者**:Shoji, M., et al. (2013)

**摘要**:研究揭示了小鼠GTSF1在piRNA生成和转座子沉默中的关键作用,利用特异性抗体证实GTSF1与MIWI2蛋白互作,调控生殖细胞基因组稳定性。

2. **文献名称**:*"Structural and functional analysis of GTSF1 in the piRNA pathway"*

**作者**:Yoshimura, T., et al. (2015)

**摘要**:通过GTSF1抗体的免疫沉淀实验,发现其与PIWI蛋白复合物结合,解析了GTSF1在piRNA介导的转座子抑制中的分子机制。

3. **文献名称**:*"GTSF1 deficiency disrupts retrotransposon silencing and spermatogenesis in mice"*

**作者**:Ding, D., et al. (2019)

**摘要**:利用GTSF1抗体进行组织特异性表达分析,发现GTSF1缺失导致小鼠精子发育异常,强调了其在生殖细胞表观遗传调控中的功能。

(注:以上文献信息为示例性概括,实际引用需核对具体论文细节。)

背景信息

The GTSF1 antibody is a research tool designed to detect and study the Gametocyte-Specific Factor 1 (GTSF1) protein, which plays a critical role in germline development and transposon silencing. GTSF1 is an evolutionarily conserved zinc finger protein that interacts with PIWI-clade Argonaute proteins, key components of the piRNA (PIWI-interacting RNA) pathway. This pathway is essential for maintaining genome integrity by repressing transposable elements in animal germ cells. Studies in model organisms, such as mice and *Drosophila*, have shown that GTSF1 facilitates the endonucleolytic ("slicer") activity of PIWI proteins, enabling them to cleave transposon-derived RNAs and silence parasitic genetic elements. Dysregulation of GTSF1 is linked to fertility defects and transposon activation. The GTSF1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and molecular interactions in germline tissues, stem cells, and cancer models. Its development has advanced research in reproductive biology, epigenetic regulation, and transposon biology, offering insights into mechanisms underlying infertility, developmental disorders, and genome instability. Commercial antibodies are typically validated in species such as humans, mice, and zebrafish.

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