Rabbit Polyclonal GTSF1 Antibody

The GTSF1 antibody is a research tool designed to detect and study the Gametocyte-Specific Factor 1 (GTSF1) protein, which plays a critical role in germline development and transposon silencing. GTSF1 is an evolutionarily conserved zinc finger protein that interacts with PIWI-clade Argonaute proteins, key components of the piRNA (PIWI-interacting RNA) pathway. This pathway is essential for maintaining genome integrity by repressing transposable elements in animal germ cells. Studies in model organisms, such as mice and *Drosophila*, have shown that GTSF1 facilitates the endonucleolytic ("slicer") activity of PIWI proteins, enabling them to cleave transposon-derived RNAs and silence parasitic genetic elements. Dysregulation of GTSF1 is linked to fertility defects and transposon activation. The GTSF1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and molecular interactions in germline tissues, stem cells, and cancer models. Its development has advanced research in reproductive biology, epigenetic regulation, and transposon biology, offering insights into mechanisms underlying infertility, developmental disorders, and genome instability. Commercial antibodies are typically validated in species such as humans, mice, and zebrafish.