Mouse Monoclonal LRP1B Antibody

The low-density lipoprotein receptor-related protein 1B (LRP1B) is a transmembrane protein belonging to the LDL receptor family, primarily involved in endocytosis, signal transduction, and cellular homeostasis. It shares structural homology with LRP1 but exhibits distinct functional properties, including roles in tumor suppression. LRP1B is frequently inactivated or deleted in various cancers, such as lung, breast, and gastric cancers, suggesting its potential as a tumor suppressor gene. LRP1B antibodies are essential tools for studying its expression, localization, and interaction partners in both normal and pathological contexts. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into its molecular mechanisms in cancer progression, metastasis, and drug resistance. Monoclonal and polyclonal LRP1B antibodies target specific domains (e.g., extracellular ligand-binding regions or cytoplasmic domains) to investigate its dual role in ligand uptake and intracellular signaling. Recent studies also explore LRP1B's involvement in neurological disorders and metabolic regulation, broadening its therapeutic relevance. Validated LRP1B antibodies are critical for diagnostic applications and preclinical studies, particularly in identifying LRP1B-deficient tumors or evaluating its prognostic value. However, challenges remain in ensuring antibody specificity due to LRP1B's structural complexity and homology with other LDL receptor family members.