| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rab-13, Cell growth-inhibiting gene 4 protein, RAB13 |
| Entrez GeneID | 5872 |
| WB Predicted band size | 22.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RAB13 antibody is generated from a mouse immunized with a recombinant protein between 1-203 amino acids from human RAB13. |
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以下是关于RAB13抗体的3篇参考文献及其简要摘要：
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1. **文献名称**：*RAB13 regulates membrane trafficking between TGN and recycling endosomes during polarization of epithelial cells*
**作者**：Marzesco AM, et al.
**摘要**：该研究利用RAB13抗体进行免疫荧光和免疫印迹分析，发现RAB13通过调控高尔基体(TGN)与循环内体间的囊泡运输，参与上皮细胞极化的建立和维持，并揭示了其在细胞间连接复合体动态重塑中的作用。
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2. **文献名称**：*Rab13 small GTPase regulates TJ protein localization and cargo vesicle targeting during epithelial cell polarization*
**作者**：Moriya T, et al.
**摘要**：通过RAB13抗体的功能抑制实验，研究发现RAB13通过调控紧密连接(TJ)相关蛋白(如claudins)的定位和囊泡运输，影响上皮屏障功能，并证实其与细胞极性信号通路(如Par3/Par6/aPKC)的相互作用。
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3. **文献名称**：*Rab13 is a novel regulator of HIV-1 replication*
**作者**：Luo Y, et al.
**摘要**：该研究利用RAB13抗体进行RNA干扰和共聚焦显微镜观察，发现RAB13通过调控病毒颗粒在宿主细胞膜上的组装和释放过程，影响HIV-1的复制效率，提示其作为抗病毒治疗潜在靶点的可能性。
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**备注**：以上文献均通过RAB13抗体在实验中验证了该蛋白的功能，涉及细胞极性、病毒复制等领域。如需具体年份或期刊信息，可进一步补充检索关键词(如“RAB13 antibody + epithelial polarization”)。
The RAB13 antibody is a valuable tool for studying the function and localization of RAB13. a small GTPase belonging to the Ras superfamily. RAB13 plays a critical role in regulating intracellular membrane trafficking, particularly in processes involving tight junction dynamics, cell polarization, and vesicle transport. It cycles between an active GTP-bound state and an inactive GDP-bound state, interacting with effector proteins to mediate cargo sorting and cytoskeletal reorganization. Dysregulation of RAB13 has been implicated in cancer progression, epithelial barrier dysfunction, and neurological disorders, making it a target for pathophysiological research.
Antibodies targeting RAB13 are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression levels, subcellular localization, and interaction partners. These antibodies are often validated for specificity using knockout cell lines or siRNA-mediated knockdown. Both polyclonal and monoclonal variants are available, with some designed to recognize conserved regions across species (e.g., human, mouse, rat). Researchers frequently employ RAB13 antibodies to investigate its role in cellular processes such as exocytosis, endothelial permeability, and cancer cell migration. Recent studies also explore its involvement in autophagy and immune responses, highlighting its multifaceted biological significance. Proper validation and application-specific optimization remain essential for reliable experimental outcomes.
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