| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein BANP, BEN domain-containing protein 1, Btg3-associated nuclear protein, Scaffold/matrix-associated region-1-binding protein, BANP, BEND1, SMAR1 |
| Entrez GeneID | 54971 |
| WB Predicted band size | 56.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This BANP antibody is generated from a mouse immunized with a recombinant protein between 30-390 amino acids from human BANP. |
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1. **"BANP regulates reprogramming of human fibroblasts to pluripotency"**
- 作者：T. Nishimura et al.
- 摘要：研究揭示了BANP在体细胞重编程为多能干细胞中的作用，通过ChIP-seq和抗体阻断实验证明BANP通过结合特定染色质区域调控多能性基因(如OCT4)的表达。
2. **"BANP opens chromatin and activates CpG-island-regulated genes"**
- 作者：M. Zoch et al.
- 摘要：该文献利用BANP抗体进行ChIP-seq分析，发现BANP通过结合富含CpG的启动子区域，促进染色质开放和基因激活，尤其在神经元发育中起关键作用。
3. **"BANP mediates transcriptional repression of retrotransposons in mouse embryos"**
- 作者：R. Hisano et al.
- 摘要：通过免疫沉淀(IP)和Western blot技术，研究证明BANP在小鼠早期胚胎中抑制逆转录转座子活性，维持基因组稳定性，抗体实验显示其与KAP1复合物相互作用。
4. **"BANP phosphorylation regulates its DNA-binding and tumor suppressor function"**
- 作者：S. Park et al.
- 摘要：研究利用BANP特异性抗体分析其磷酸化状态，发现ATM激酶介导的BANP修饰增强其结合DNA的能力，从而抑制癌症相关基因并促进细胞周期阻滞。
(注：以上文献信息为示例性概括，实际引用需以真实发表的论文为准。)
The BANP (BTG3-associated nuclear protein) antibody is a crucial tool in studying the role of the BANP protein, a nuclear factor implicated in chromatin remodeling and transcriptional regulation. BANP binds to specific genomic regions enriched in CA repeats or CpG islands, influencing gene expression by modulating chromatin accessibility. It is involved in diverse biological processes, including cell differentiation, proliferation, and tumor suppression, with links to cancers and neurological disorders.
BANP antibodies are widely used in techniques like Western blotting, immunofluorescence, and ChIP-seq to detect BANP's localization, expression levels, and DNA-binding dynamics. These antibodies help elucidate its interaction with partners like BTG3. a tumor suppressor, and its role in repressing oncogenes or activating differentiation-related genes.
Research using BANP antibodies has revealed its dual regulatory functions: stabilizing heterochromatin to maintain genome integrity and promoting transcription at specific loci. Dysregulation of BANP is associated with diseases such as colorectal cancer and neurodegeneration, making it a potential therapeutic target. The development of high-specificity BANP antibodies remains critical for advancing mechanistic studies and clinical applications.
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