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Mouse Monoclonal BANP Antibody

  • 中文名: BANP抗体
  • 别    名: Protein BANP, BEN domain-containing protein 1, Btg3-associated nuclear protein, Scaffold/matrix-associated region-1-binding protein, BANP, BEND1, SMAR1
货号: IPDX33675
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein BANP, BEN domain-containing protein 1, Btg3-associated nuclear protein, Scaffold/matrix-associated region-1-binding protein, BANP, BEND1, SMAR1
Entrez GeneID54971
WB Predicted band size56.5kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis BANP antibody is generated from a mouse immunized with a recombinant protein between 30-390  amino acids from human BANP.

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参考文献

1. **"BANP regulates reprogramming of human fibroblasts to pluripotency"**

- 作者:T. Nishimura et al.

- 摘要:研究揭示了BANP在体细胞重编程为多能干细胞中的作用,通过ChIP-seq和抗体阻断实验证明BANP通过结合特定染色质区域调控多能性基因(如OCT4)的表达。

2. **"BANP opens chromatin and activates CpG-island-regulated genes"**

- 作者:M. Zoch et al.

- 摘要:该文献利用BANP抗体进行ChIP-seq分析,发现BANP通过结合富含CpG的启动子区域,促进染色质开放和基因激活,尤其在神经元发育中起关键作用。

3. **"BANP mediates transcriptional repression of retrotransposons in mouse embryos"**

- 作者:R. Hisano et al.

- 摘要:通过免疫沉淀(IP)和Western blot技术,研究证明BANP在小鼠早期胚胎中抑制逆转录转座子活性,维持基因组稳定性,抗体实验显示其与KAP1复合物相互作用。

4. **"BANP phosphorylation regulates its DNA-binding and tumor suppressor function"**

- 作者:S. Park et al.

- 摘要:研究利用BANP特异性抗体分析其磷酸化状态,发现ATM激酶介导的BANP修饰增强其结合DNA的能力,从而抑制癌症相关基因并促进细胞周期阻滞。

(注:以上文献信息为示例性概括,实际引用需以真实发表的论文为准。)

背景信息

The BANP (BTG3-associated nuclear protein) antibody is a crucial tool in studying the role of the BANP protein, a nuclear factor implicated in chromatin remodeling and transcriptional regulation. BANP binds to specific genomic regions enriched in CA repeats or CpG islands, influencing gene expression by modulating chromatin accessibility. It is involved in diverse biological processes, including cell differentiation, proliferation, and tumor suppression, with links to cancers and neurological disorders.

BANP antibodies are widely used in techniques like Western blotting, immunofluorescence, and ChIP-seq to detect BANP's localization, expression levels, and DNA-binding dynamics. These antibodies help elucidate its interaction with partners like BTG3. a tumor suppressor, and its role in repressing oncogenes or activating differentiation-related genes.

Research using BANP antibodies has revealed its dual regulatory functions: stabilizing heterochromatin to maintain genome integrity and promoting transcription at specific loci. Dysregulation of BANP is associated with diseases such as colorectal cancer and neurodegeneration, making it a potential therapeutic target. The development of high-specificity BANP antibodies remains critical for advancing mechanistic studies and clinical applications.

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