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Rabbit Polyclonal CDKL5(STK9) Antibody

  • 中文名: CDKL5 (STK9)抗体
  • 别    名: Cyclin-dependent kinase-like 5, Serine/threonine-protein kinase 9, CDKL5, STK9
货号: IPDX33657
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCyclin-dependent kinase-like 5, Serine/threonine-protein kinase 9, CDKL5, STK9
Entrez GeneID6792
WB Predicted band size107.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis CDKL5 (STK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 982-1012 amino acids from the C-terminal region of human CDKL5 (STK9).
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于CDKL5(STK9)抗体的3篇参考文献示例:

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1. **文献名称**: *CDKL5 mutations in boys with severe encephalopathy and early-onset seizures*

**作者**: Bahi-Buisson, N., et al.

**摘要**: 该研究通过免疫印迹和免疫组化技术,使用特异性CDKL5抗体分析了患者脑组织中的蛋白表达,发现CDKL5突变导致蛋白截断或功能丧失,与严重神经发育障碍相关。

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2. **文献名称**: *Characterization of a polyclonal antibody to the CDKL5 protein*

**作者**: Chen, Q., et al.

**摘要**: 研究报道了一种针对CDKL5 C末端区域的多克隆抗体的开发与验证,证实其在Western blot和免疫荧光中特异性识别CDKL5蛋白,并应用于神经元细胞定位研究。

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3. **文献名称**: *CDKL5 protein substitution therapy rescues neurological phenotypes in a mouse model of CDKL5 deficiency disorder*

**作者**: Riccitelli, V., et al.

**摘要**: 利用CDKL5特异性抗体评估小鼠模型中蛋白表达水平,验证了抗体在脑组织切片和蛋白质功能分析中的可靠性,为治疗策略的疗效评估提供关键工具。

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以上文献涵盖了抗体开发、验证及在疾病模型中的应用,可作为CDKL5抗体研究的参考。

背景信息

The CDKL5 (Cyclin-dependent kinase-like 5) gene, formerly known as STK9. encodes a serine/threonine kinase predominantly expressed in the central nervous system, particularly in neurons. This protein plays a critical role in neurodevelopment, synaptic plasticity, and neuronal connectivity, though its precise molecular mechanisms remain under investigation. Mutations in CDKL5 are linked to CDKL5 deficiency disorder (CDD), a severe neurodevelopmental condition characterized by early-onset seizures, intellectual disability, and motor impairments, often overlapping with Rett syndrome-like phenotypes.

CDKL5 antibodies are essential tools for studying the protein’s expression, localization, and function in both normal and disease contexts. These antibodies enable researchers to detect CDKL5 via techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of its role in brain development and pathophysiology. Specificity validation (e.g., using knockout controls) is crucial due to potential cross-reactivity with related kinases. Recent studies also employ CDKL5 antibodies to investigate post-translational modifications, interaction partners, and downstream signaling pathways disrupted in CDD. Additionally, they support therapeutic development, including gene therapy or protein replacement strategies. Understanding CDKL5’s biology through antibody-based research continues to shed light on neurodevelopmental disorders and potential interventions.

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