| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Krueppel-like factor 11, Transforming growth factor-beta-inducible early growth response protein 2, TGFB-inducible early growth response protein 2, TIEG-2, KLF11, FKLF, TIEG2 |
| Entrez GeneID | 8462 |
| WB Predicted band size | 55.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TIEG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human TIEG2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于TIEG2 (N-term)抗体的3-4篇参考文献的简要概括(文献为模拟示例，非真实存在)：
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1. **文献名称**: *"Characterization of TIEG2/KLF11 as a TGF-β-inducible transcription factor and its role in apoptosis"*
**作者**: John, S. et al.
**摘要**: 研究通过生成针对TIEG2 N末端的多克隆抗体，验证了其在TGF-β信号通路中的表达和核定位。抗体经Western blot和免疫荧光验证，证实TIEG2在细胞凋亡中的调控作用。
2. **文献名称**: *"Development and application of a TIEG2-specific antibody for studying pancreatic cancer progression"*
**作者**: Zhang, L. et al.
**摘要**: 开发了一种靶向TIEG2 N端的单克隆抗体，用于胰腺癌组织的免疫组化分析，发现TIEG2表达下调与肿瘤侵袭性相关，提示其作为抑癌因子的潜力。
3. **文献名称**: *"TIEG2/KLF11 regulates oxidative stress responses via Nrf2 signaling: Antibody validation in knockout models"*
**作者**: Chen, H. et al.
**摘要**: 通过兔源TIEG2 N-term抗体在基因敲除模型中的特异性验证，揭示了TIEG2通过Nrf2通路调控氧化应激的分子机制。
4. **文献名称**: *"Epigenetic modulation of TIEG2 in cardiac fibrosis: Role of a novel N-terminal targeted antibody"*
**作者**: Smith, R. et al.
**摘要**: 利用新型TIEG2 N-term抗体进行染色质免疫沉淀(ChIP)，证明TIEG2与纤维化相关基因启动子结合，参与心脏纤维化的表观遗传调控。
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如需真实文献，建议通过PubMed或Google Scholar以关键词“TIEG2 antibody N-terminal”“KLF11 antibody”进一步检索。
**Background of TIEG2 (N-term) Antibody**
The TIEG2 (N-term) antibody is a tool designed to detect the N-terminal region of TIEG2 (TGF-β Inducible Early Gene 2), a transcription factor also known as Krüppel-like factor 11 (KLF11). TIEG2 belongs to the Krüppel-like factor (KLF) family, which regulates gene expression by binding to GC-rich DNA sequences. It is involved in diverse cellular processes, including apoptosis, differentiation, and response to TGF-β signaling.
TIEG2 is characterized by three zinc finger motifs at its C-terminal domain, which mediate DNA binding, and an N-terminal domain that interacts with co-regulators to modulate transcriptional activity. The N-term antibody specifically targets epitopes in the N-terminal region, enabling researchers to study TIEG2’s expression, localization, and protein interactions in various biological contexts.
This antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate TIEG2’s role in diseases such as cancer, fibrosis, and neurodegenerative disorders. Studies highlight its importance in TGF-β-mediated pathways, cellular stress responses, and epigenetic regulation. By detecting TIEG2 in tissue or cell lysates, the antibody aids in understanding its tissue-specific functions and potential as a therapeutic target.
Validated for specificity and sensitivity, the TIEG2 (N-term) antibody serves as a critical reagent for exploring molecular mechanisms underlying development, homeostasis, and pathology linked to KLF family proteins.
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