首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal TCTA(N-Term) Antibody

  • 中文名: TCTA (N-Term)抗体
  • 别    名: T-cell leukemia translocation-altered gene protein, T-cell leukemia translocation-associated gene protein, TCTA
货号: IPDX33637
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesT-cell leukemia translocation-altered gene protein, T-cell leukemia translocation-associated gene protein, TCTA
Entrez GeneID6988
WB Predicted band size11.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis TCTA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 23-55 amino acids from human TCTA.

+ +

参考文献

以下是关于TCTA (N-Term)抗体的参考文献示例(内容为模拟,仅供参考):

---

1. **"A novel monoclonal antibody targeting the N-terminal domain of TCTA (ARID3B) reveals its nuclear localization in cancer cells"**

*Authors: Smith J, et al.*

摘要:本研究开发了一种特异性识别TCTA蛋白N端结构域的单克隆抗体,验证了其在Western blot和免疫荧光中的高特异性,并发现TCTA在多种癌细胞核中异常表达,可能与转录调控相关。

2. **"Functional characterization of TCTA in hematopoiesis using N-terminal specific antibodies"**

*Authors: Tanaka K, et al.*

摘要:通过针对TCTA N端的抗体,研究证实其在造血干细胞分化中的关键作用,抗体通过阻断N端功能域抑制了白血病细胞的增殖,提示其作为治疗靶点的潜力。

3. **"Development of a polyclonal anti-TCTA (N-Term) antibody for detecting epigenetic modifications in solid tumors"**

*Authors: Lee S, et al.*

摘要:报道了一种兔源多克隆抗体的制备,特异性靶向TCTA的N端表位,应用于免疫组化分析,显示TCTA在乳腺癌和肺癌组织中的表达与患者预后显著相关。

4. **"TCTA/ARID3B N-terminal interactions: structural insights from antibody-mediated inhibition assays"**

*Authors: Garcia-Ruiz C, et al.*

摘要:利用N端抗体研究TCTA的蛋白互作网络,发现其N端结构域与染色质重塑复合物结合,为解析TCTA在基因沉默中的机制提供了新证据。

---

*注:以上文献为示例性质,实际引用请通过学术数据库(如PubMed、Web of Science)检索真实发表的研究。*

背景信息

The TCTA (N-Term) antibody is a specific immunological tool designed to detect the N-terminal region of the TRAPPC4 protein (Trafficking Protein Particle Complex subunit 4), also known as TCTA. TRAPPC4 is a critical component of the TRAPP (Transport Protein Particle) complex, which plays a key role in intracellular vesicular trafficking, particularly in regulating Golgi-to-ER retrograde transport and maintaining Golgi structure. This antibody is commonly used in research to study TRAPPC4's expression, localization, and function in cellular processes such as membrane trafficking, autophagy, and cell signaling. It is widely applied in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate TRAPPC4's involvement in diseases, including cancer and neurodegenerative disorders. The N-Term specificity ensures targeted recognition of the protein's initial segment, aiding in distinguishing full-length TRAPPC4 from potential splice variants or degradation products. Validated for specificity and sensitivity, the TCTA (N-Term) antibody serves as a crucial reagent for elucidating the molecular mechanisms of TRAPP complex-mediated trafficking pathways and their physiological relevance.

客户数据及评论

折叠内容

大包装询价

×