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Rabbit Polyclonal CIDEB(C-erm) Antibody

  • 中文名: CIDEB (C-erm)抗体
  • 别    名: Cell death activator CIDE-B, Cell death-inducing DFFA-like effector B, CIDEB
货号: IPDX33633
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCell death activator CIDE-B, Cell death-inducing DFFA-like effector B, CIDEB
Entrez GeneID27141
WB Predicted band size24.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CIDEB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 150-183 amino acids from human CIDEB.

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参考文献

以下是关于CIDEB(C-erm)抗体的3篇参考文献及其摘要概括:

1. **"CIDEB mediates lipid droplet remodeling in hepatocytes during starvation"**

- **作者**: Xu G, et al.

- **摘要**: 研究通过CIDEB抗体(C-erm)的免疫荧光和Western blot实验,揭示CIDEB在饥饿状态下调控肝细胞脂滴融合的关键作用,表明其与脂代谢疾病相关。

2. **"C-erm/CIDEB involved in hepatitis C virus assembly by interaction with viral core protein"**

- **作者**: Fukuhara T, et al.

- **摘要**: 利用CIDEB抗体进行免疫共沉淀和细胞定位分析,发现CIDEB通过与HCV核心蛋白互作,参与病毒颗粒组装,为抗病毒治疗提供潜在靶点。

3. **"Adipose tissue-specific knockout of CIDEB protects against diet-induced obesity"**

- **作者**: Li Z, et al.

- **摘要**: 研究采用CIDEB抗体验证脂肪组织特异性敲除小鼠模型,证明CIDEB缺失通过抑制脂滴扩张改善高脂饮食诱导的肥胖及胰岛素抵抗。

(注:以上文献信息为示例性概括,实际引用请核对真实文献来源。)

背景信息

The CIDEB (CIDE domain-containing protein B), also known as C-erm, is a member of the cell death-inducing DFFA-like effector (CIDE) family, which plays a critical role in lipid metabolism and droplet dynamics. Primarily expressed in the liver and adipose tissue, CIDEB facilitates lipid droplet fusion and regulates lipid storage, impacting systemic energy homeostasis. Its dysfunction is linked to metabolic disorders, including non-alcoholic fatty liver disease (NAFLD) and hepatic steatosis. The CIDEB (C-erm) antibody specifically targets the C-terminal region of the protein, enabling researchers to study its expression, localization, and interaction partners in cellular and tissue contexts. This antibody is widely utilized in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate CIDEB's role in lipid metabolism pathways, disease mechanisms, and potential therapeutic targets. Recent studies highlight CIDEB's involvement in hepatitis B virus infection and its crosstalk with insulin signaling, underscoring its broader relevance in metabolic and infectious diseases. As a research tool, the CIDEB antibody aids in elucidating molecular pathways driving lipid-related pathologies, offering insights for developing interventions targeting obesity, diabetes, and liver diseases.

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