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Rabbit Polyclonal C18orf32 Antibody

  • 中文名: C18orf32抗体
  • 别    名: UPF0729 protein C18orf32, Putative NF-kappa-B-activating protein 200, C18orf32
货号: IPDX33632
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUPF0729 protein C18orf32, Putative NF-kappa-B-activating protein 200, C18orf32
Entrez GeneID497661
WB Predicted band size8.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis C18orf32 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 26-58 amino acids from human C18orf32.

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参考文献

以下是关于C18orf32抗体的示例性参考文献(注:实际文献可能有限,以下内容为模拟示例):

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1. **文献名称**: *"Characterization of a novel polyclonal antibody against human C18orf32 protein"*

**作者**: Zhang Y, et al.

**摘要**: 本研究开发了一种针对C18orf32蛋白的多克隆抗体,通过免疫兔获得并验证其特异性。Western blot和免疫荧光结果显示该抗体可特异性识别内源性C18orf32蛋白,并发现其在多种癌细胞系中表达上调,提示其潜在功能与肿瘤发生相关。

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2. **文献名称**: *"C18orf32 expression in colorectal cancer: A prognostic biomarker study using immunohistochemistry"*

**作者**: Smith JL, et al.

**摘要**: 利用商业化C18orf32抗体对结直肠癌组织进行免疫组化分析,发现C18orf32高表达与患者不良预后显著相关。研究进一步提示C18orf32可能通过调控Wnt/β-catenin通路促进肿瘤侵袭。

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3. **文献名称**: *"Functional analysis of C18orf32 in neuronal development using CRISPR and antibody-based silencing"*

**作者**: Wang H, et al.

**摘要**: 结合CRISPR基因编辑和C18orf32抗体介导的蛋白敲降技术,证明C18orf32在小鼠神经元突触形成中起关键作用。抗体特异性验证显示其适用于体外和体内模型的功能研究。

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4. **文献名称**: *"C18orf32 interacts with mitochondrial proteins: Evidence from co-immunoprecipitation assays"*

**作者**: Kim S, et al.

**摘要**: 使用C18orf32抗体进行免疫共沉淀实验,发现该蛋白与线粒体复合物I组分存在相互作用,提示其可能参与能量代谢调控,为研究代谢性疾病提供了新方向。

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**注**:以上文献为模拟示例,实际研究中C18orf32的相关报道较少,建议通过数据库(如PubMed、Google Scholar)以“C18orf32 antibody”或“C18orf32 protein function”为关键词检索最新进展。

背景信息

The C18orf32 antibody is a research tool designed to detect the protein product of the *C18orf32* gene (Chromosome 18 Open Reading Frame 32), a poorly characterized human gene located on chromosome 18. The gene encodes a protein with unknown molecular function, though bioinformatic analyses suggest potential roles in intracellular signaling or protein-protein interactions due to conserved structural motifs. Limited studies indicate *C18orf32* may be expressed in various tissues, including the brain, testis, and certain cancer cells, but its physiological relevance remains unclear. Antibodies targeting C18orf32 are typically polyclonal or monoclonal reagents developed for applications like Western blotting, immunohistochemistry, or immunofluorescence to map protein expression patterns, subcellular localization, or interactions. These antibodies are critical for exploratory studies aiming to link *C18orf32* to specific pathways, diseases (e.g., cancer, neurological disorders), or developmental processes. Validation data often emphasize specificity through knockout controls or epitope mapping. Despite its enigmatic role, interest in C18orf32 persists due to genomic associations with disease susceptibility loci and evolutionary conservation across vertebrates, hinting at potential biological significance yet to be fully elucidated. Ongoing research using such antibodies seeks to clarify its contribution to cellular mechanisms and pathology.

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