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Rabbit Polyclonal UBE2L6 Antibody

  • 中文名: UBE2L6抗体
  • 别    名: Ubiquitin/ISG15-conjugating enzyme E2 L6, Retinoic acid-induced gene B protein, RIG-B, UbcH8, Ubiquitin carrier protein L6, Ubiquitin-protein ligase L6, UBE2L6, UBCH8
货号: IPDX33627
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUbiquitin/ISG15-conjugating enzyme E2 L6, Retinoic acid-induced gene B protein, RIG-B, UbcH8, Ubiquitin carrier protein L6, Ubiquitin-protein ligase L6, UBE2L6, UBCH8
Entrez GeneID9246
WB Predicted band size17.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis UBE2L6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-153 amino acids from the C-terminal region of human UBE2L6.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于UBE2L6抗体的3篇参考文献示例(注:内容为模拟概括,实际文献请通过学术数据库核实):

1. **文献名称**: *UBE2L6 regulates HCV replication through ISGylation-dependent antiviral immunity*

**作者**: Zhang Y, et al.

**摘要**: 本研究利用UBE2L6特异性抗体进行Western blot分析,发现UBE2L6通过介导ISG15修饰(ISGylation)抑制丙型肝炎病毒(HCV)复制,揭示了其在宿主抗病毒反应中的关键作用。

2. **文献名称**: *UBE2L6 promotes breast cancer progression via modulating EGFR stability*

**作者**: Tanaka K, et al.

**摘要**: 通过免疫组化实验(使用UBE2L6抗体)发现,UBE2L6在乳腺癌组织中高表达,并通过泛素化通路调控EGFR蛋白稳定性,促进肿瘤侵袭和转移。

3. **文献名称**: *Characterization of UBE2L6 knockout mice using antibody-based proteomic profiling*

**作者**: Lee S, et al.

**摘要**: 研究通过UBE2L6抗体验证基因敲除小鼠模型,证实UBE2L6缺失导致干扰素信号通路异常,为自身免疫性疾病机制研究提供了新线索。

如需具体文献,建议在PubMed或Web of Science中以“UBE2L6 antibody”为关键词检索,并筛选涉及该抗体实验应用的论文。

背景信息

The UBE2L6 antibody is a research tool targeting UBE2L6 (Ubiquitin-Conjugating Enzyme E2 L6), a member of the E2 ubiquitin-conjugating enzyme family involved in the ubiquitin-proteasome system. UBE2L6. also known as UBCH8. facilitates the transfer of ubiquitin to substrate proteins in conjunction with E3 ligases, regulating processes like protein degradation, signal transduction, and immune responses. It specifically catalyzes the formation of K29- or K33-linked polyubiquitin chains, distinguishing it from other E2 enzymes. UBE2L6 is notably implicated in interferon signaling pathways, where it interacts with STAT proteins to modulate antiviral and inflammatory responses. Dysregulation of UBE2L6 has been linked to cancers, autoimmune disorders (e.g., lupus), and viral infections. Antibodies against UBE2L6 are widely used in Western blotting, immunoprecipitation, and immunofluorescence to study its expression, localization, and interactions in cellular models or clinical samples. They help elucidate its role in ubiquitination cascades and disease mechanisms. Validated UBE2L6 antibodies are critical for ensuring specificity, particularly given the structural similarities among E2 enzymes. Research utilizing these antibodies has advanced understanding of UBE2L6's dual role in promoting tumorigenesis (via oncoprotein stabilization) or acting as a tumor suppressor (by degrading oncogenic substrates), highlighting its context-dependent functions. Such studies underscore its potential as a therapeutic target or biomarker in precision medicine.

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