| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Procollagen C-endopeptidase enhancer 2, Procollagen COOH-terminal proteinase enhancer 2, PCPE-2, Procollagen C-proteinase enhancer 2, PCOLCE2, PCPE2 |
| Entrez GeneID | 26577 |
| WB Predicted band size | 45.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PCOLCE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human PCOLCE2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PCOLCE2抗体的3篇参考文献示例(基于公开研究内容概括，非真实文献，仅供格式参考)：
1. **文献名称**：*PCOLCE2 regulates collagen fibrillogenesis in dermal fibrosis via BMP-1 interaction*
**作者**：Smith A, et al.
**摘要**：研究通过PCOLCE2抗体进行免疫共沉淀和Western blot分析，发现PCOLCE2通过与BMP-1结合增强胶原蛋白的成熟，在皮肤纤维化模型中表达显著上调。
2. **文献名称**：*Procollagen C-proteinase enhancer 2 (PCOLCE2) as a potential biomarker in osteoarthritis*
**作者**：Chen L, et al.
**摘要**：利用PCOLCE2抗体进行免疫组化分析，发现其在骨关节炎患者的软骨组织中异常高表达，可能与胶原降解和关节退变相关。
3. **文献名称**：*Expression profiling of PCOLCE2 in tumor stroma using a novel monoclonal antibody*
**作者**：Wang Y, et al.
**摘要**：开发了一种高特异性PCOLCE2单克隆抗体，并通过免疫荧光证实其在多种肿瘤基质中高表达，提示其可能参与肿瘤微环境中胶原重塑的调控。
(注：以上为模拟内容，实际文献需通过PubMed或SciHub等平台检索。)
PCOLCE2 (procollagen C-endopeptidase enhancer 2) is a secreted glycoprotein belonging to the procollagen C-proteinase enhancer (PCOLCE) family. It shares structural homology with PCOLCE1. including a conserved N-terminal CUB domain and a C-terminal netrin-like domain. PCOLCE2 enhances the enzymatic activity of bone morphogenetic protein-1 (BMP-1)/tolloid-like proteases, which play critical roles in extracellular matrix (ECM) remodeling by processing procollagens and other ECM-associated proteins. While less studied than PCOLCE1. PCOLCE2 is implicated in tissue repair, development, and pathological fibrosis. Its expression is detected in various tissues, particularly in regions undergoing active ECM reorganization, such as healing wounds or fibrotic lesions.
PCOLCE2 antibodies are essential tools for investigating the protein's expression, localization, and functional interactions. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study PCOLCE2's role in physiological processes and diseases, including cancer progression and organ fibrosis. Some studies suggest PCOLCE2 may influence tumor microenvironment dynamics by modulating ECM stiffness and growth factor availability. Commercial PCOLCE2 antibodies are typically raised against specific epitopes, often in rabbit or mouse hosts, with validation in knockdown models or recombinant protein systems. Research applications focus on elucidating its regulatory mechanisms in ECM homeostasis and potential as a biomarker or therapeutic target in fibrotic disorders.
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