| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase 10, Lymphocyte-oriented kinase, Stk10, Lok |
| Entrez GeneID | 20868 |
| WB Predicted band size | 111.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Stk10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 668-696 amino acids from the C-terminal region of mouse Stk10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及小鼠STK10蛋白及其抗体的参考文献示例(注：以下内容为模拟示例，实际文献可能需要通过学术数据库验证)：
1. **文献名称**: "STK10 regulates T-cell migration through phosphorylation of ERM proteins"
**作者**: Li et al. (2018)
**摘要**: 研究利用小鼠STK10特异性抗体，通过Western blot和免疫荧光分析发现，STK10通过磷酸化Ezrin/Radixin/Moesin(ERM)蛋白调控T细胞的迁移能力，揭示其在免疫细胞功能中的关键作用。
2. **文献名称**: "Genetic ablation of Stk10 in mice reveals its role in lymphoid organ development"
**作者**: Smith et al. (2016)
**摘要**: 通过构建Stk10基因敲除小鼠模型，结合抗体介导的蛋白检测，证明STK10缺失导致脾脏和淋巴结结构异常，提示其参与淋巴组织发育调控。
3. **文献名称**: "Characterization of STK10 kinase activity in B-cell malignancies"
**作者**: Wang et al. (2020)
**摘要**: 利用小鼠源性STK10抗体进行免疫沉淀及激酶活性分析，发现STK10在B细胞肿瘤中异常活化，可能与MAPK信号通路调控相关，为靶向治疗提供依据。
**提示**：实际文献需通过PubMed、Google Scholar等平台以关键词“Mouse STK10 antibody”或“STK10 kinase function”检索。部分研究可能未直接使用抗体但涉及STK10功能，可结合上下文筛选。
The Mouse Stk10 (Serine/Threonine Kinase 10) antibody is a tool used to detect and study the Stk10 protein, a member of the germinal center kinase (GCK) family. Stk10. also known as LOSK or SLK, is a ubiquitously expressed kinase involved in regulating cytoskeletal dynamics, cell migration, proliferation, and apoptosis. It contains a N-terminal kinase domain and a C-terminal citron homology (CNH) or pleckstrin homology (PH)-like domain, enabling interactions with signaling molecules and membranes. Stk10 plays roles in immune cell function, particularly T-cell activation and trafficking, by modulating actin reorganization and integrin signaling. Dysregulation of Stk10 has been linked to cancer metastasis, immune disorders, and neurological diseases.
The Mouse Stk10 antibody is typically generated using recombinant protein fragments or peptides specific to murine Stk10. ensuring species specificity. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess Stk10 expression, localization, and post-translational modifications in mouse tissues or cell lines. Validated applications include studying Stk10's role in tumor invasiveness, immune responses, and cell signaling pathways. Researchers rely on this antibody to explore Stk10's mechanistic contributions to disease models, aiding drug discovery and therapeutic targeting. Proper validation (e.g., knockout controls) is essential to confirm antibody specificity due to potential cross-reactivity with related kinases.
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