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Rabbit Polyclonal C9 Antibody

  • 中文名: C9抗体
  • 别    名: Complement component C9, Complement component C9a, Complement component C9b, C9
货号: IPDX33613
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下是3-4条关于C9抗体的**模拟参考文献**(内容为示例,非真实文献):

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1. **文献名称**:*Anti-C9 Antibody Attenuates Complement-Mediated Neuronal Injury in Alzheimer’s Disease Models*

**作者**:Smith A, et al.

**摘要**:研究证明,针对补体C9的单克隆抗体可有效抑制β-淀粉样蛋白诱导的膜攻击复合物(MAC)形成,减轻阿尔茨海默病模型中的神经元损伤和炎症反应。

2. **文献名称**:*Neutralizing C9 Antibody Therapy Reduces Hemolysis in Paroxysmal Nocturnal Hemoglobinuria*

**作者**:Johnson B, et al.

**摘要**:通过体外和动物模型实验,发现C9中和抗体能够阻断补体终末途径,抑制红细胞裂解,为阵发性夜间血红蛋白尿(PNH)提供新型治疗策略。

3. **文献名称**:*Structural Basis of C9 Inhibition by a Humanized Antibody in Autoimmune Disorders*

**作者**:Lee C, et al.

**摘要**:利用冷冻电镜技术解析C9抗体与靶点的结合机制,揭示其通过阻断C9聚合抑制MAC形成,为自身免疫性疾病(如狼疮性肾炎)的靶向治疗提供依据。

4. **文献名称**:*C9 Antibody Mitigates Ischemia-Reperfusion Injury via Complement Pathway Suppression*

**作者**:Wang D, et al.

**摘要**:在心肌缺血再灌注损伤模型中,C9抗体显著减少补体激活导致的组织损伤,提示其在器官移植和心血管疾病中的潜在应用价值。

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**注**:以上为模拟文献,实际研究中请参考真实发表的学术论文(可通过PubMed、Google Scholar等平台检索)。

背景信息

The C9 antibody targets the complement component 9 (C9), a key protein in the terminal pathway of the complement system, an essential part of innate immunity. C9 is a glycoprotein that polymerizes with other complement components (C5b, C6. C7. C8) to form the membrane attack complex (MAC), which lyses pathogens by creating pores in their membranes. Dysregulation of MAC formation is implicated in various inflammatory and autoimmune diseases, including atypical hemolytic uremic syndrome (aHUS), age-related macular degeneration (AMD), and neurodegenerative disorders. C9 antibodies are primarily used in research to study MAC assembly, localization, and its role in disease pathogenesis. In clinical contexts, anti-C9 therapies are being explored to inhibit excessive MAC activity, which can cause tissue damage. Additionally, C9 autoantibodies have been identified in certain autoimmune conditions, suggesting diagnostic or prognostic relevance. Recent studies also highlight the potential of C9-targeting monoclonal antibodies in treating complement-mediated disorders. The development of these antibodies underscores the dual role of MAC in host defense and pathology, driving interest in therapeutic strategies to modulate its activity.

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