| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger and BTB domain-containing protein 11, ZBTB11 |
| Entrez GeneID | 27107 |
| WB Predicted band size | 119.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZBTB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 736-765 amino acids from the C-terminal region of human ZBTB11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZBTB11抗体的假设性参考文献示例(注：实际文献可能需要通过学术数据库验证，以下内容为模拟创作)：
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1. **文献名称**: "ZBTB11 promotes colorectal cancer progression through transcriptional repression of tumor suppressor genes"
**作者**: Smith J, et al.
**摘要**: 本研究利用ZBTB11特异性抗体进行Western blot和免疫组化(IHC)分析，发现ZBTB11在结直肠癌组织中显著高表达，并与患者生存率降低相关。机制研究表明，ZBTB11通过抑制抑癌基因的转录促进肿瘤侵袭。
2. **文献名称**: "ZBTB11 regulates neuronal differentiation via chromatin remodeling complexes"
**作者**: Brown L, et al.
**摘要**: 通过ZBTB11抗体进行染色质免疫沉淀(ChIP)和免疫荧光实验，发现ZBTB11与染色质重塑复合物相互作用，调控神经干细胞分化相关基因的表达，影响小鼠大脑发育。
3. **文献名称**: "Characterization of a novel polyclonal antibody against human ZBTB11 for functional studies"
**作者**: Garcia R, et al.
**摘要**: 本文报道了一种新型兔源ZBTB11多克隆抗体的开发，验证了其在免疫沉淀(IP)和免疫细胞化学中的特异性，为研究ZBTB11的亚细胞定位及蛋白互作提供了可靠工具。
4. **文献名称**: "ZBTB11 mediates metabolic reprogramming in hepatocellular carcinoma"
**作者**: Lee H, et al.
**摘要**: 使用ZBTB11抗体进行功能缺失实验，发现ZBTB11通过调控糖酵解相关基因的转录，驱动肝癌细胞的代谢重编程，提示其作为潜在治疗靶点。
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**注意事项**：
- 以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索确认。
- 可尝试关键词："ZBTB11 antibody"、"ZBTB11 immunohistochemistry"、"ZBTB11 ChIP-seq"。
- 若研究较少，可扩大检索范围至ZBTB11的功能研究(如转录调控、癌症关联等)。
The ZBTB11 antibody targets the zinc finger and BTB domain-containing protein 11 (ZBTB11), a transcriptional regulator belonging to the BTB/POZ-zinc finger family. ZBTB11 is evolutionarily conserved and ubiquitously expressed, with roles in cell cycle regulation, DNA damage response, and chromatin remodeling. Structurally, it contains a BTB domain for protein interactions and multiple C2H2 zinc finger motifs for DNA binding. Studies suggest ZBTB11 participates in transcriptional repression by recruiting histone deacetylases (HDACs) and other chromatin-modifying complexes, though its exact mechanisms remain under investigation.
ZBTB11 antibodies are critical tools for studying its expression patterns, subcellular localization (primarily nuclear), and interactions in diseases. Dysregulation of ZBTB11 has been implicated in cancers, including hepatocellular carcinoma and glioblastoma, where it may act as an oncogene or tumor suppressor depending on context. Antibodies against ZBTB11 enable detection via Western blotting, immunohistochemistry, and immunofluorescence, aiding research into its functional roles. Recent work also links ZBTB11 mutations to neurodevelopmental disorders, highlighting its importance in neural differentiation. However, commercial ZBTB11 antibodies require rigorous validation due to potential cross-reactivity with homologous proteins. Ongoing research aims to clarify ZBTB11's tissue-specific functions and therapeutic potential.
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