| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-aminobutyric acid receptor subunit rho-3, GABA(A) receptor subunit rho-3, GABA(C) receptor, GABRR3 |
| Entrez GeneID | 200959 |
| WB Predicted band size | 54.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GBRR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-63 amino acids from the N-terminal region of human GBRR3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GABRR3(γ-氨基丁酸受体ρ3亚基，N端抗体)的假设性参考文献示例(请注意，**GBRR3可能存在拼写错误，建议核实目标蛋白名称**)：
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1. **文献名称**: "Characterization of a Novel Polyclonal Antibody Targeting the N-Terminal Domain of GABRR3 for Immunohistochemical Applications"
**作者**: Smith J, et al.
**摘要**: 本研究报道了一种针对GABRR3蛋白N端结构域的多克隆抗体的开发与验证。通过Western blot和免疫组化实验，证明该抗体在啮齿类动物视网膜组织中特异性识别GABRR3.并揭示了其在抑制性神经突触中的表达模式。
2. **文献名称**: "GABRR3 N-Terminal Antibody Reveals Dysregulated Expression in Epilepsy Models"
**作者**: Lee H, et al.
**摘要**: 利用GABRR3 (N-term)抗体探究癫痫小鼠模型中受体亚基的分布变化。结果显示，海马区GABRR3表达显著下调，提示其可能通过调节GABA能信号通路参与癫痫发生。
3. **文献名称**: "Structural Insights into GABAA ρ3 Subunit Using Epitope-Specific Antibodies"
**作者**: Garcia-Rodriguez C, et al.
**摘要**: 通过N端特异性抗体结合冷冻电镜技术，解析了GABRR3在受体复合物中的构象变化，为理解其介导的神经信号传递机制提供了结构生物学依据。
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**注意**：以上文献为示例，实际研究中请通过PubMed或Google Scholar检索真实文献(关键词：GABRR3 antibody、GABA receptor rho3 subunit)。若目标蛋白名称有误，建议确认后重新检索。
The GBRR3 (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the N-terminal region of the GABA Rho3 receptor subunit (GABRR3), a component of the GABAC receptor family. GABAC receptors, primarily composed of ρ subunits (ρ1. ρ2. ρ3), are ligand-gated chloride channels mediating inhibitory neurotransmission in the central nervous system. Unlike GABAA receptors, GABAC receptors exhibit high sensitivity to GABA and slower desensitization kinetics. The GABRR3 subunit is predominantly expressed in the retina, brain, and spinal cord, where it contributes to visual processing, synaptic plasticity, and modulation of neuronal excitability.
The GBRR3 (N-term) antibody is commonly used in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect the expression and localization of GABRR3 in tissue samples or cell lines. Its specificity for the N-terminal epitope ensures recognition of full-length or partially processed forms of the protein, aiding in studies of receptor assembly, trafficking, and post-translational modifications. Validation often includes knockout controls or peptide blocking assays to confirm target specificity.
Research involving this antibody has shed light on GABAC receptor roles in retinal degeneration, epilepsy, and neurodevelopmental disorders. Dysregulation of GABRR3 has been linked to impaired visual signaling and neurological pathologies, making this antibody a critical tool for exploring GABAergic signaling mechanisms and potential therapeutic targets. Host species (e.g., rabbit, mouse) and reactivity (human, rat, mouse) vary by commercial source, requiring optimization for experimental conditions.
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