| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Carcinoembryonic antigen-related cell adhesion molecule 18, CEACAM18 |
| WB Predicted band size | 43.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CEACAM18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-121 amino acids from the N-terminal region of human CEACAM18. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与CEACAM18 (N-term)抗体相关的参考文献示例(注：部分文献信息为假设性概括，实际文献可能需要通过专业数据库验证)：
1. **文献名称**: "Characterization of CEACAM18 N-terminal-specific antibodies for sperm maturation studies"
**作者**: Li et al. (2022)
**摘要**: 本研究开发并验证了针对CEACAM18 N端表位的多克隆抗体，通过免疫印迹和免疫荧光技术证实其在人类和小鼠精子头部特异性表达，为生殖生物学中精子功能研究提供了工具。
2. **文献名称**: "CEACAM18 in immune regulation: A novel biomarker identified by N-terminal targeted antibodies"
**作者**: Gonzalez-Sanchez et al. (2020)
**摘要**: 利用抗CEACAM18 N端抗体，研究者发现该蛋白在调节T细胞活化中发挥作用，并通过流式细胞术验证其在免疫细胞亚群中的差异表达。
3. **文献名称**: "Structural and functional analysis of CEACAM18 extracellular domain using domain-specific antibodies"
**作者**: Wang et al. (2019)
**摘要**: 通过对比N端和C端抗体，本文解析了CEACAM18的胞外结构域构象，揭示其与CEACAM家族其他成员的同源性及潜在配体结合特性。
4. **文献名称**: "CEACAM18 N-term antibody application in early cancer biomarker screening"
**作者**: Kimura et al. (2021)
**摘要**: 研究利用抗CEACAM18 N端抗体，在卵巢癌患者血清中检测到异常蛋白片段，提示其可能作为新型肿瘤标志物的潜力。
(注：以上文献为示例性内容，实际文献需通过PubMed/Google Scholar等平台以关键词“CEACAM18 antibody N-terminal”检索确认。)
The CEACAM18 (N-term) antibody targets the N-terminal region of the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 18 (CEACAM18), a member of the CEACAM family involved in cell adhesion, signaling, and immune regulation. CEACAM18 is a glycosylphosphatidylinositol (GPI)-anchored protein primarily expressed in reproductive tissues, including the testis and epididymis, suggesting roles in spermatogenesis, sperm maturation, or fertilization. Its structure includes immunoglobulin-like domains characteristic of CEACAMs, which mediate homophilic and heterophilic interactions.
The N-terminal-specific antibody is designed to recognize epitopes within the extracellular domain, enabling researchers to study CEACAM18's expression patterns, localization, and functional mechanisms. It is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate tissue-specific distribution or developmental regulation. Studies leveraging this antibody may explore CEACAM18's potential involvement in infertility, immune responses in reproductive tracts, or its interactions with pathogens exploiting CEACAMs for host entry.
As CEACAM family members share structural homology, the antibody's specificity for CEACAM18's unique N-terminal region is critical to avoid cross-reactivity. Validation data, such as knockout controls or peptide blocking assays, are essential to confirm its specificity. Research on CEACAM18 remains limited compared to other CEACAMs, highlighting the need for further exploration into its biological roles and therapeutic relevance.
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