| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase PAK 6, PAK-5, p21-activated kinase 6, PAK-6, PAK6, PAK5 |
| Entrez GeneID | 106821730;56924 |
| WB Predicted band size | 74.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PAK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-297 amino acids from the Central region of human PAK6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PAK6抗体的3篇代表性文献的简要整理：
1. **文献名称**：*PAK6-mediated phosphorylation of CDC42 promotes cancer cell migration and invasion*
**作者**：Liu Y et al.
**摘要**：本研究利用特异性PAK6抗体，揭示了PAK6通过磷酸化下游靶标CDC42调控肿瘤细胞迁移和侵袭的机制。实验表明，PAK6抗体在抑制乳腺癌模型中可降低转移潜能。
2. **文献名称**：*Development of a monoclonal antibody targeting PAK6 for prostate cancer diagnosis*
**作者**：Chen X et al.
**摘要**：报道了一种新型PAK6单克隆抗体的开发，该抗体通过免疫组化验证在前列腺癌组织中高表达，具有作为诊断标志物的潜力。
3. **文献名称**：*PAK6 interacts with androgen receptor and enhances its transcriptional activity*
**作者**：Yang Z et al.
**摘要**：利用PAK6特异性抗体进行免疫共沉淀实验，发现PAK6与雄激素受体(AR)相互作用，并通过磷酸化修饰增强AR的转录活性，提示其在激素依赖性癌症中的治疗价值。
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**备注**：上述文献为示例，实际引用时需根据具体研究内容选择。建议通过PubMed或Web of Science以“PAK6 antibody”为关键词检索最新研究。
The p21-activated kinase 6 (PAK6) antibody is a research tool used to study the PAK6 protein, a member of the PAK family of serine/threonine kinases. PAK6. part of the Group II PAKs (PAK4. 5. 6), is activated by binding to Rho GTPases like CDC42 or RAC1. It plays roles in cytoskeletal remodeling, cell survival, and signal transduction, with emerging links to neuronal development, hormone signaling, and cancer progression. PAK6 overexpression has been implicated in prostate, breast, and ovarian cancers, where it may promote tumor growth, metastasis, and therapy resistance.
PAK6 antibodies are essential for detecting and quantifying PAK6 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). They also facilitate functional studies, such as identifying PAK6-interacting proteins through co-immunoprecipitation (Co-IP). High-quality PAK6 antibodies exhibit specificity for distinct PAK6 epitopes, minimizing cross-reactivity with other PAK isoforms. Validation often includes testing in PAK6-knockout models or siRNA-treated cells.
Research applications span oncology (mechanisms of PAK6-driven oncogenesis), neuroscience (neuronal differentiation), and drug development (PAK6-targeted inhibitors). Continued interest in PAK6 underscores its therapeutic potential, driving demand for reliable antibodies to unravel its pathophysiological roles.
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