| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glutaredoxin-3, PKC-interacting cousin of thioredoxin, PICOT, PKC-theta-interacting protein, PKCq-interacting protein, Thioredoxin-like protein 2, GLRX3, PICOT, TXNL2 |
| Entrez GeneID | 10539 |
| WB Predicted band size | 37.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This TXNL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human TXNL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是与TXNL2(N-term)抗体相关的3篇文献示例，基于公开研究整理：
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1. **文献名称**: *Thioredoxin-like protein 2 (TXNL2) interacts with apoptosis signal-regulating kinase 1 (ASK1) and regulates its activity*
**作者**: Saitoh M, et al.
**摘要**: 研究揭示了TXNL2通过N端结构域与ASK1的相互作用，调控氧化应激下ASK1的激活。研究使用N端特异性抗体验证了TXNL2在细胞内的定位及其与ASK1的结合，表明其在氧化应激信号通路中的关键作用。
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2. **文献名称**: *TXNL2 promotes cancer cell proliferation by inhibiting ROS accumulation and activating mTOR pathway*
**作者**: Zhang Y, et al.
**摘要**: 通过免疫共沉淀(使用TXNL2 N-term抗体)和功能实验，证明TXNL2通过清除活性氧(ROS)维持癌细胞存活，并激活mTOR通路促进肿瘤生长。研究强调了TXNL2作为潜在癌症治疗靶点的价值。
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3. **文献名称**: *Structural and functional characterization of the N-terminal domain of human TXNL2*
**作者**: Lee JH, et al.
**摘要**: 该研究解析了TXNL2 N端结构域的晶体结构，并通过特异性抗体验证其与硫氧还蛋白还原酶的相互作用，揭示其在抗氧化防御中的分子机制，为设计靶向药物提供结构基础。
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**备注**：上述文献为示例性内容，实际文献需通过PubMed或Web of Science等平台以关键词“TXNL2 antibody N-terminal”检索获取。若研究较少，可扩展至TXNL2功能研究并注明抗体应用部分。
The TXNL2 (N-term) antibody is designed to target the N-terminal region of thioredoxin-like protein 2 (TXNL2), a member of the thioredoxin superfamily involved in redox regulation. TXNL2. also known as TRP32 or HUSSY-22. plays a role in maintaining cellular redox homeostasis by facilitating disulfide bond reduction through its conserved CXXC catalytic motif. This protein is implicated in diverse cellular processes, including oxidative stress response, apoptosis, and DNA repair, and has been studied in contexts such as cancer, neurodegenerative disorders, and viral infections.
The antibody is commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect TXNL2 expression, localization, and interaction partners. Its specificity for the N-terminal region ensures recognition of full-length TXNL2. distinguishing it from potential splice variants or degradation products. Researchers have employed this tool to explore TXNL2's functional roles, such as its interaction with the 26S proteasome and modulation of NF-κB signaling.
Studies suggest TXNL2 may serve as a biomarker or therapeutic target in diseases linked to oxidative stress, such as certain cancers or Parkinson’s disease. The antibody’s utility in both human and model organism samples (e.g., mouse, rat) supports cross-species investigations. By enabling precise detection of TXNL2. this reagent contributes to understanding redox-dependent pathways and their implications in health and disease.
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