| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sodium-coupled monocarboxylate transporter 2, Electroneutral sodium monocarboxylate cotransporter, Low-affinity sodium-lactate cotransporter, Solute carrier family 5 member 12, SLC5A12, SMCT2 |
| Entrez GeneID | 159963 |
| WB Predicted band size | 67.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SLC5A12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 576-605 amino acids from the C-terminal region of human SLC5A12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于SLC5A12抗体的3篇参考文献示例(文献信息为虚构模拟，仅作参考)：
---
1. **文献名称**：*SLC5A12 functions as a lactate transporter in the kidney*
**作者**：Gopal E, et al.
**摘要**：本研究通过免疫组化(IHC)和Western blot技术，使用SLC5A12特异性抗体验证了其在近端肾小管上皮细胞中的表达，并证实其作为乳酸转运体的功能，参与酸碱平衡调节。
---
2. **文献名称**：*Expression profiling of SLC5A12 in intestinal epithelial cells*
**作者**：Coady MJ, et al.
**摘要**：利用抗SLC5A12抗体进行免疫荧光染色和流式细胞术，揭示了该转运蛋白在小肠上皮细胞顶膜的高表达，提示其在短链脂肪酸吸收中的潜在作用。
---
3. **文献名称**：*SLC5A12 as a biomarker in glioblastoma: Immunohistochemical analysis*
**作者**：Bhutia YD, et al.
**摘要**：通过SLC5A12抗体对胶质母细胞瘤组织进行免疫组化分析，发现其表达水平与肿瘤代谢重编程相关，可能作为癌症治疗的潜在靶点。
---
**备注**：以上文献信息为模拟示例，实际研究中建议通过PubMed或Google Scholar以关键词“SLC5A12 antibody”或“SLC5A12 immunohistochemistry”检索真实文献。
The SLC5A12 antibody targets the solute carrier family 5 member 12 (SLC5A12), a sodium-coupled monocarboxylate transporter responsible for facilitating the cellular uptake of lactate, short-chain fatty acids, and other metabolites. SLC5A12 is predominantly expressed in the kidney, intestine, and certain cancer cells, where it plays critical roles in pH regulation, energy metabolism, and nutrient absorption. In renal proximal tubules, it mediates lactate reabsorption, influencing systemic acid-base balance. Its involvement in cancer metabolism, particularly in tumors reliant on lactate shuttling for energy, has garnered recent research interest.
Antibodies against SLC5A12 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate tissue-specific distribution or dysregulation in diseases. For instance, SLC5A12 overexpression has been linked to diabetic nephropathy and metabolic acidosis, while its role in tumor microenvironments highlights potential therapeutic targets. Researchers also employ these antibodies to explore SLC5A12's interaction with signaling pathways or its response to metabolic stressors. Validation of antibody specificity is crucial, often confirmed via knockout controls or siRNA-based silencing. As interest in metabolic transporters grows, SLC5A12 antibodies remain pivotal in elucidating its contributions to health and disease.
×
