| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription regulator protein BACH2, BTB and CNC homolog 2, BACH2 |
| Entrez GeneID | 60468 |
| WB Predicted band size | 92.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This BACH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 815-841 amino acids from the C-terminal region of human BACH2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于BACH2抗体的3篇文献示例(注：内容为模拟概括，实际文献需通过数据库验证)：
1. **文献名称**：*BACH2 mediates CD4+ T cell quiescence and limits autoimmune pathology*
**作者**：Roychoudhuri, R. et al.
**摘要**：研究利用BACH2抗体进行ChIP-seq和免疫印迹分析，发现BACH2通过抑制效应T细胞过度活化维持免疫稳态，其缺失导致自身免疫性疾病易感性增加。
2. **文献名称**：*BACH2 regulates the CD8+ T cell response to infection by controlling chromatin accessibility*
**作者**：Tsukumo, S. et al.
**摘要**：通过BACH2抗体的染色质免疫共沉淀(ChIP)实验，揭示BACH2通过调控染色质可及性限制CD8+ T细胞的过度增殖，影响抗病毒免疫应答。
3. **文献名称**：*BACH2 promotes B cell survival and function by repressing oxidative stress pathways*
**作者**：Watanabe, A. et al.
**摘要**：使用BACH2抗体的免疫组化和基因敲除模型，证明BACH2通过抑制活性氧(ROS)相关基因表达维持B细胞存活及抗体类别转换重组功能。
如需具体文献，建议通过PubMed或Google Scholar以“BACH2 antibody”及研究主题(如免疫调控、癌症)为关键词检索。
**Background of BACH2 Antibody**
BACH2 (BTB and CNC homology 1. basic leucine zipper transcription factor 2) is a transcription regulator critical for immune system function, particularly in B-cell and T-cell development, differentiation, and antibody class-switching. It belongs to the Cap'n'collar (CNC) family of basic leucine zipper (bZIP) proteins and acts as a tumor suppressor by repressing genes involved in oxidative stress responses and cell proliferation. BACH2 also regulates the balance between immune activation and tolerance, impacting autoimmune diseases, allergies, and cancer.
BACH2 antibodies are immunological tools designed to detect and study the expression, localization, and function of the BACH2 protein. These antibodies are typically developed using immunogenic peptides or recombinant protein fragments, often targeting specific domains like the BTB (Bric-a-brac, Tramtrack, Broad Complex) domain or the bZIP DNA-binding region. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP-seq).
Research utilizing BACH2 antibodies has elucidated its role in lymphoid maturation, immune memory, and its interaction with partners like MAF proteins to modulate gene expression. Dysregulation of BACH2 is linked to malignancies (e.g., lymphoma), autoimmune disorders, and immunodeficiency, making it a biomarker and therapeutic target. Validated BACH2 antibodies are essential for advancing studies in immunology, oncology, and molecular pathology.
×
