| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein LAP2, Densin-180-like protein, Erbb2-interacting protein, Erbin, ERBB2IP, ERBIN, KIAA1225, LAP2 |
| Entrez GeneID | 55914 |
| WB Predicted band size | 158.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This LAP2 antibody is generated from a mouse immunized with a recombinant protein of human LAP2. |
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以下是关于LAP2抗体的3篇代表性文献，按研究领域分类整理：
1. **文献名称**：*"Lamina-associated polypeptide 2 (LAP2) regulates nuclear envelope assembly and chromatin organization"*
**作者**：Foisner, R. et al.
**摘要**：研究通过LAP2抗体免疫定位，揭示LAP2蛋白在核膜重组和染色质锚定中的关键作用，证明其缺失导致核膜结构异常。
2. **文献名称**：*"Dysregulation of LAP2 expression in gastric cancer progression"*
**作者**：Wang, L. et al.
**摘要**：利用LAP2抗体进行免疫组化分析，发现胃癌组织中LAP2表达显著下调，且与肿瘤分化程度和转移呈负相关。
3. **文献名称**：*"Antibody-specific detection of LAP2 isoforms in progeroid syndromes"*
**作者**：Dechat, T. et al.
**摘要**：开发特异性识别LAP2不同剪接变体的抗体，并验证其在早衰症患者细胞中检测核膜蛋白异常定位的应用价值。
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**提示**：LAP2抗体常用于核膜相关疾病研究(如早衰症、癌症)及细胞周期调控实验，建议根据具体实验目的(WB/IF/IHC)选择经文献验证的抗体克隆号。
**Background of LAP2 Antibody**
LAP2 (lamina-associated polypeptide 2) is a family of nuclear envelope proteins encoded by the *TMPO* gene, with multiple isoforms generated through alternative splicing. These isoforms, including LAP2α and LAP2β, localize to distinct nuclear compartments: LAP2α associates with the nucleoplasm, while LAP2β binds the inner nuclear membrane. They interact with lamins (e.g., lamin B) and chromatin, playing critical roles in nuclear structure maintenance, chromatin organization, and cell cycle regulation. LAP2β, for instance, is essential for nuclear envelope reassembly post-mitosis.
LAP2 antibodies are widely used tools in research to study nuclear architecture, mitotic dynamics, and diseases linked to nuclear envelope dysfunction, such as cardiomyopathies, laminopathies, and premature aging syndromes. These antibodies enable detection of LAP2 isoforms via techniques like immunofluorescence, Western blotting, and immunohistochemistry. Dysregulation of LAP2 expression or mutations in *TMPO* have been implicated in disrupted nuclear integrity and disease pathogenesis, making LAP2 antibodies valuable for investigating molecular mechanisms underlying these conditions. Their specificity for distinct isoforms also aids in dissecting isoform-specific functions in health and disease.
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