| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger and BTB domain-containing protein 7B, Krueppel-related zinc finger protein cKrox, hcKrox, T-helper-inducing POZ/Krueppel-like factor, Zinc finger and BTB domain-containing protein 15, Zinc finger protein 67 homolog, Zfp-67, Zinc finger protein 857B, Zinc finger protein Th-POK, ZBTB7B, ZBTB15, ZFP67, ZNF857B |
| Entrez GeneID | 51043 |
| WB Predicted band size | 58.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZBTB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-469 amino acids from the C-terminal region of human ZBTB7B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是3篇与ZBTB7B抗体相关的虚拟参考文献示例(注：内容为模拟生成，非真实文献)：
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1. **文献名称**: *ZBTB7B regulates Th17 cell differentiation through transcriptional repression of RORγt*
**作者**: Lazarevic V, et al.
**摘要**: 本研究利用ZBTB7B特异性抗体进行ChIP-seq分析，发现ZBTB7B通过直接结合RORγt基因启动子抑制其表达，从而调控Th17细胞分化，揭示了其在自身免疫疾病中的潜在作用。
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2. **文献名称**: *ZBTB7B as a novel prognostic marker in hepatocellular carcinoma*
**作者**: Liu Y, Zhang H.
**摘要**: 通过免疫组化(使用ZBTB7B单克隆抗体)分析肝癌组织样本，发现ZBTB7B低表达与患者不良预后显著相关，其机制可能与抑制肿瘤细胞EMT过程有关。
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3. **文献名称**: *Structural insights into ZBTB7B-DNA interaction by cryo-EM*
**作者**: Omori SA, et al.
**摘要**: 结合ZBTB7B抗体进行免疫共沉淀及冷冻电镜技术，解析了ZBTB7B蛋白与靶DNA的结合构象，为设计靶向该转录因子的小分子药物提供结构基础。
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如需真实文献，建议在PubMed或Google Scholar检索关键词“ZBTB7B antibody”或“ZBTB7B function”。
The ZBTB7B antibody is a crucial tool in studying the function and expression of ZBTB7B, a transcription factor belonging to the zinc finger and BTB/POZ domain-containing protein family. Also known as Th-POK or cKrox, ZBTB7B plays a pivotal role in immune regulation, particularly in T-cell lineage commitment and differentiation. It is essential for the development of CD4+ helper T cells while suppressing CD8+ cytotoxic T-cell fate, making it a key regulator of adaptive immunity.
ZBTB7B antibodies are widely used in research to detect and quantify the protein’s expression in various biological samples through techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate ZBTB7B’s involvement in immune responses, cancer progression, and metabolic diseases. For instance, ZBTB7B has been implicated in tumor suppression or promotion, depending on cellular context, and its dysregulation is linked to autoimmune disorders.
The development of high-specificity ZBTB7B antibodies has advanced studies on its molecular mechanisms, including interactions with transcriptional co-repressors and chromatin remodeling complexes. Researchers also utilize these antibodies to explore ZBTB7B’s role in epigenetic regulation and its potential as a therapeutic target. Validated antibodies with minimal cross-reactivity ensure reliable data, aiding in the translation of basic research into clinical applications.
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