Rabbit Polyclonal PCDH10(N-Term) Antibody

The PCDH10 (N-Term) antibody is a targeted immunological reagent designed to detect the N-terminal region of Protocadherin 10 (PCDH10), a member of the cadherin superfamily. PCDH10 is a calcium-dependent cell-cell adhesion protein encoded by the *PCDH10* gene, located on human chromosome 4q28.3. It plays critical roles in neural development, synaptic plasticity, and tumor suppression. Structurally, PCDH10 contains extracellular cadherin repeats for calcium-dependent homophilic binding, a transmembrane domain, and a cytoplasmic tail involved in intracellular signaling. Dysregulation of PCDH10 has been implicated in cancers (e.g., glioblastoma, lung, and colorectal cancers) due to its role in suppressing proliferation, invasion, and metastasis, often via promoter hypermethylation-mediated silencing. In neurological contexts, PCDH10 is associated with neurodevelopmental disorders, including autism spectrum disorders. The N-Term-specific antibody enables researchers to study PCDH10 expression, localization, and function in tissues or cell lines using techniques like immunohistochemistry (IHC), Western blot (WB), or immunofluorescence (IF). Its specificity for the N-terminal region ensures recognition of full-length, functional protein, distinguishing it from potential cleavage products. This antibody serves as a vital tool for exploring PCDH10's mechanistic roles in disease pathways and its potential as a biomarker or therapeutic target.