| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Embryonal Fyn-associated substrate, hEFS, Cas scaffolding protein family member 3, EFS, CASS3 |
| Entrez GeneID | 10278 |
| WB Predicted band size | 58.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This EFS antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 367-399 amino acids from the Central region of human EFS. |
+ +
以下为3-4条关于EFS抗体的示例参考文献(注：以下为虚构示例，实际文献请通过学术数据库查询)：
---
1. **文献名称**: "EFS Antibody Characterization in Tumor Microenvironment Modulation"
**作者**: Smith A, et al.
**摘要**: 研究利用抗EFS单克隆抗体分析肿瘤微环境中EFS蛋白的表达，发现其与免疫抑制性细胞浸润相关，提示EFS可能作为癌症免疫治疗的潜在靶点。
2. **文献名称**: "Development of a High-Affinity EFS Antibody for Neurological Disorders"
**作者**: Lee B, et al.
**摘要**: 报道了一种高特异性抗EFS多克隆抗体的开发，通过阻断EFS蛋白在小鼠模型中的活性，验证了其在神经退行性疾病中的病理作用。
3. **文献名称**: "EFS Antibody-Based Detection in Triple-Negative Breast Cancer Prognosis"
**作者**: García-Ruiz C, et al.
**摘要**: 利用免疫组化技术结合抗EFS抗体，发现EFS过表达与三阴性乳腺癌患者的总生存率降低显著相关，为预后标志物研究提供依据。
4. **文献名称**: "Structural Insights into EFS Protein Using Monoclonal Antibody Binding"
**作者**: Tanaka K, et al.
**摘要**: 通过单克隆抗体与EFS蛋白的晶体结构分析，揭示了EFS的功能域构象，为设计靶向抑制剂奠定结构基础。
---
建议通过 **PubMed、Web of Science 或 Google Scholar** 搜索真实文献，关键词如 "EFS antibody"、"EFS protein function" 或结合具体研究领域(如肿瘤学、神经科学)。
EFS antibody targets the E74-like factor 5 (ELF5), a member of the ETS transcription factor family, which plays critical roles in embryonic development, tissue differentiation, and cancer biology. ELF5 is notably involved in epithelial cell differentiation, particularly in mammary gland development, where it regulates genes essential for alveolar maturation and lactation. It also influences cell fate decisions by modulating proliferation, apoptosis, and epithelial-mesenchymal transition (EMT). Dysregulation of ELF5 is linked to multiple cancers, acting as a tumor suppressor in breast and prostate cancers by inhibiting oncogenic pathways, while paradoxically promoting metastasis in certain contexts.
EFS antibodies are vital tools for detecting ELF5 expression in research and diagnostics. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to localize ELF5 in tissues or cells, aiding studies on its role in development and disease. In cancer research, these antibodies help assess ELF5’s prognostic value, as reduced expression often correlates with aggressive tumor behavior. Additionally, they are used to investigate ELF5’s interaction with signaling pathways (e.g., TGF-β, Wnt) and its epigenetic regulation. Available as monoclonal or polyclonal versions from various host species, EFS antibodies support both basic research and clinical applications, bridging mechanistic insights with potential therapeutic targeting.
×
