| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Deoxyribonuclease-1-like 2, 3.1.21.-, DNase I homolog protein DHP1, Deoxyribonuclease I-like 2, DNase I-like 2, DNASE1L2, DHP1, DNAS1L2 |
| Entrez GeneID | 1775 |
| WB Predicted band size | 32.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DNASE1L2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 199-229 amino acids from human DNASE1L2. |
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以下是关于DNASE1L2抗体的3篇参考文献示例(部分内容为模拟，仅供参考)：
1. **文献名称**：*DNASE1L2 as a novel biomarker for colorectal cancer progression*
**作者**：Smith A, et al.
**摘要**：本研究通过开发特异性DNASE1L2抗体，证实其在结直肠癌组织中高表达，并与肿瘤侵袭性相关。抗体用于免疫组化分析，结果显示DNASE1L2可能成为潜在治疗靶点。
2. **文献名称**：*Characterization of monoclonal antibodies against human DNASE1L2 for apoptosis studies*
**作者**：Lee H, et al.
**摘要**：文章报道了一种针对人DNASE1L2蛋白的单克隆抗体制备，验证其在Western blot和流式细胞术中的应用，揭示了DNASE1L2在细胞凋亡中的调控作用。
3. **文献名称**：*DNASE1L2 autoantibodies in systemic lupus erythematosus*
**作者**：Garcia R, et al.
**摘要**：研究利用DNASE1L2抗体检测系统性红斑狼疮(SLE)患者血清中的自身抗体水平，发现其与疾病活动度相关，提示DNASE1L2可能参与SLE的病理机制。
4. **文献名称**：*DNASE1L2 expression profiling in neurodegenerative disorders*
**作者**：Chen L, et al.
**摘要**：通过特异性抗体分析脑组织样本，发现DNASE1L2在阿尔茨海默病患者中表达异常，可能与神经元DNA损伤修复通路相关。
(注：以上文献信息为模拟生成，实际引用需以真实数据库检索结果为准。)
The DNASE1L2 antibody targets the Deoxyribonuclease 1-Like 2 (DNASE1L2) protein, a member of the DNase I family involved in DNA degradation. DNASE1L2 is encoded by the DNASE1L2 gene and shares structural similarities with DNase I, including conserved catalytic residues critical for endonucleolytic cleavage of DNA. Unlike the secreted DNase I, DNASE1L2 is thought to function intracellularly, potentially playing roles in apoptosis, chromatin breakdown during cell death, or processing of mitochondrial DNA. Its expression is tissue-specific, with higher levels observed in skin, suggesting a possible link to dermatological conditions or barrier function.
Antibodies against DNASE1L2 are utilized in research to study its localization, expression patterns, and molecular interactions. They are commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using these antibodies have explored DNASE1L2's potential involvement in autoimmune diseases, cancer (e.g., melanoma), and rare genetic disorders. However, the protein's precise biological functions remain partially characterized, partly due to its overlapping enzymatic activities with other DNases. DNASE1L2 antibodies also serve as tools to investigate its distinction from related family members like DNASE1L1 and DNASE1L3. aiding in elucidating isoform-specific pathways. Validation of antibody specificity is crucial due to potential cross-reactivity within this conserved enzyme family.
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