Rabbit Polyclonal NMNAT1 Antibody

NMNAT1 (nicotinamide mononucleotide adenylyltransferase 1) is a nuclear enzyme that catalyzes the final step in nicotinamide adenine dinucleotide (NAD+) biosynthesis, converting nicotinamide mononucleotide (NMN) and ATP to NAD+. As a member of the NMNAT family, NMNAT1 plays a critical role in maintaining cellular NAD+ levels, which are essential for energy metabolism, DNA repair, and calcium signaling. It is ubiquitously expressed but particularly vital in neurons, where NAD+ depletion has been linked to neurodegenerative disorders like Alzheimer’s disease and axon degeneration. NMNAT1 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies enable researchers to detect NMNAT1 protein levels via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Studies using NMNAT1-specific antibodies have revealed its neuroprotective properties, including its role in mitigating oxidative stress and stabilizing mitochondrial function. Additionally, NMNAT1 antibodies help distinguish it from other isoforms (NMNAT2 and NMNAT3), which exhibit distinct subcellular distributions and tissue-specific functions. Validated antibodies are crucial for exploring NMNAT1's potential as a therapeutic target or biomarker in age-related diseases, metabolic syndromes, and neurodegeneration. Proper validation via knockout controls or siRNA knockdown ensures specificity, minimizing cross-reactivity with homologous proteins.