| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myb-related protein B, B-Myb, Myb-like protein 2, MYBL2, BMYB |
| Entrez GeneID | 4605 |
| WB Predicted band size | 78.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MYBL2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 245-278 amino acids from the Central region of human MYBL2. |
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以下是关于MYBL2抗体的3篇文献示例(内容为虚构，仅作格式参考)：
1. **文献名称**: *MYBL2 Expression in Triple-Negative Breast Cancer: Prognostic Implications*
**作者**: Zhang L, et al.
**摘要**: 本研究通过免疫组化(IHC)和Western blot分析，验证了MYBL2抗体在乳腺癌组织中的特异性，发现MYBL2高表达与患者预后不良及肿瘤转移显著相关。
2. **文献名称**: *Development of a Novel Monoclonal Antibody for MYBL2 and Its Application in Glioblastoma*
**作者**: Patel R, et al.
**摘要**: 文章报道了一种高特异性抗MYBL2单克隆抗体的开发，并通过流式细胞术和免疫荧光验证其在胶质母细胞瘤细胞系中的检测效果，证明MYBL2在肿瘤干细胞中异常激活。
3. **文献名称**: *MYBL2 Regulates Cell Cycle Progression in Colorectal Cancer via p53 Pathway*
**作者**: Kim S, et al.
**摘要**: 利用MYBL2抗体进行染色质免疫沉淀(ChIP)和蛋白质印迹分析，揭示了MYBL2通过调控p53相关基因驱动结直肠癌细胞周期进程的分子机制。
(注：以上文献为模拟示例，实际研究中请通过PubMed或Google Scholar检索真实文献。)
The MYBL2 antibody is a tool used to detect MYBL2 (MYB proto-oncogene like 2), a transcription factor belonging to the MYB family. MYBL2. also known as B-Myb, plays a critical role in regulating cell cycle progression, proliferation, and differentiation by controlling the expression of genes involved in G2/M phase transition and mitotic processes. It is ubiquitously expressed in proliferating cells and interacts with other proteins like LIN9 or FOXM1 to maintain genomic stability. Dysregulation of MYBL2 has been linked to various cancers, including breast, liver, and colorectal tumors, where its overexpression often correlates with poor prognosis, metastasis, and therapy resistance.
The MYBL2 antibody is commonly used in research to study its expression patterns, subcellular localization, and functional roles in both normal and pathological conditions. It is validated for techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Depending on the clone, the antibody may recognize specific isoforms or post-translational modifications. Researchers rely on its specificity to investigate MYBL2’s involvement in oncogenesis, cell cycle checkpoints, or DNA damage responses. Commercial antibodies often include validation data (e.g., siRNA knockdown, knockout cell lines) to confirm target specificity. Proper controls and optimized protocols are essential, as MYBL2 shares structural homology with other MYB family members. Its applications extend to biomarker studies, drug development, and mechanistic explorations in cancer biology.
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