首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal IDNK(N-Term) Antibody

  • 中文名: IDNK (N-Term)抗体
  • 别    名: Probable gluconokinase, Gluconate kinase, IDNK, C9orf103
货号: IPDX33553
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/8000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProbable gluconokinase, Gluconate kinase, IDNK, C9orf103
Entrez GeneID414328
WB Predicted band size20.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis IDNK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 11-45 amino acids from human IDNK.

+ +

参考文献

以下是关于IDNK (N-Term)抗体的参考文献示例(内容基于假设性文献,若需真实文献请核实基因名称或补充信息):

---

1. **文献名称**: *"Characterization of IDNK N-Terminal Antibody for Metabolic Enzyme Studies"*

**作者**: Smith A, et al.

**摘要**: 本研究开发并验证了一种针对IDNK蛋白N端结构域的高特异性多克隆抗体。通过Western blot和免疫荧光技术,证实该抗体在哺乳动物细胞中能有效检测IDNK的表达,并用于研究其在戊糖代谢途径中的功能定位。

2. **文献名称**: *"IDNK Antibody Application in Plant Stress Response Analysis"*

**作者**: Lee C, Kim D.

**摘要**: 文章利用IDNK (N-Term)单克隆抗体,探究植物在氧化应激下IDNK的表达变化。实验表明,该抗体具有高亲和力,可用于免疫组化及蛋白质相互作用研究,揭示了IDNK在应激信号通路中的潜在作用。

3. **文献名称**: *"Development of a Novel Anti-IDNK Antibody for Cancer Biomarker Screening"*

**作者**: Gonzalez R, et al.

**摘要**: 研究团队报道了一种新型抗IDNK N端抗体,用于癌症患者的组织微阵列分析。抗体通过ELISA和免疫沉淀验证,显示其在结直肠癌样本中IDNK表达上调,提示其作为生物标志物的可能性。

4. **文献名称**: *"Structural Insights into IDNK Using Domain-Specific Antibodies"*

**作者**: Patel S, et al.

**摘要**: 通过结合N端和C端特异性抗体,本研究解析了IDKN蛋白的构效关系。N端抗体帮助鉴定了该区域在酶活性调控中的关键作用,为靶向药物设计提供了依据。

---

**注意**:以上文献为示例性内容,实际研究中IDNK可能涉及不同功能或别名。若检索困难,建议:

1. 确认基因名称准确性(如IDNK可能对应“戊糖代谢相关酶”或UniProt中的特定条目);

2. 在PubMed或Google Scholar中搜索 **"IDKN antibody N-terminal"** 或联系抗体供应商获取引用文献。

背景信息

The IDNK (N-Term) antibody is designed to target the N-terminal region of the isocitrate dehydrogenase 1 (IDH1) protein, a key enzyme in cellular metabolism. IDH1 catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG) in the tricarboxylic acid (TCA) cycle and plays a critical role in maintaining redox balance and biosynthetic precursor supply. Mutations in IDH1. particularly at arginine 132 (R132), are frequently observed in cancers such as gliomas, acute myeloid leukemia (AML), and chondrosarcomas. These mutations confer neomorphic activity, enabling IDH1 to produce the oncometabolite D-2-hydroxyglutarate (D-2HG), which disrupts cellular epigenetics and promotes tumorigenesis. The N-Term-specific antibody allows researchers to distinguish wild-type IDH1 from mutant variants, aiding in the study of IDH1's physiological roles and its pathological contributions in cancer. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess IDH1 expression, localization, and mutation status in clinical and preclinical samples. This antibody is crucial for advancing research into IDH1-targeted therapies and understanding metabolic reprogramming in cancer.

客户数据及评论

折叠内容

大包装询价

×