| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Etoposide-induced protein 24 homolog, p53-induced gene 8 protein, EI24, PIG8 |
| Entrez GeneID | 9538 |
| WB Predicted band size | 39.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This EI24 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 27-61 amino acids from human EI24. |
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以下是3篇与EI24 (N-Term)抗体相关的文献概览：
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1. **文献名称**：*EI24 regulates autophagy via the ATG5 interaction in breast cancer cells*
**作者**：Smith J. et al.
**摘要**：该研究利用EI24 (N-Term)特异性抗体进行免疫沉淀实验，发现EI24通过结合自噬关键蛋白ATG5调控乳腺癌细胞自噬，揭示了其在肿瘤抑制中的新机制。
2. **文献名称**：*EI24 deficiency promotes hepatocellular carcinoma progression through mitochondrial dysfunction*
**作者**：Li Y. et al.
**摘要**：通过EI24 (N-Term)抗体的Western blot分析，发现EI24缺失导致肝癌细胞线粒体功能异常，促进肿瘤生长，提示其作为肝癌治疗靶点的潜力。
3. **文献名称**：*EI24-mediated apoptosis in response to DNA damage requires its nuclear localization*
**作者**：Wang H. et al.
**摘要**：使用EI24 (N-Term)抗体的免疫荧光实验证实，DNA损伤时EI24向细胞核转位并激活p53依赖的凋亡通路，强调了其亚细胞定位的功能重要性。
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**注**：以上文献为示例性内容，实际文献需通过PubMed或Google Scholar以关键词“EI24 antibody N-Term”或“EI24 autophagy/apoptosis”检索最新研究。建议结合具体实验需求筛选针对性文献。
The EI24 (N-Term) antibody is designed to detect the N-terminal region of the EI24 protein, a molecule encoded by the *EI24* gene (also known as *ETEA* or *PRCC-TFE3-regulated like*). EI24 (Etoposide-Induced 24) was initially identified as a p53-regulated gene induced during DNA damage and apoptosis. The protein plays critical roles in endoplasmic reticulum (ER) stress response, autophagy, and programmed cell death. It localizes to the ER membrane and participates in ER-associated degradation (ERAD), helping to maintain cellular homeostasis by clearing misfolded proteins. EI24 also interacts with Bcl-2 family proteins to modulate apoptosis and has been implicated in tumor suppression, with its dysregulation linked to cancers and neurodegenerative disorders.
The EI24 (N-Term) antibody is commonly used in research applications like Western blotting, immunohistochemistry, and immunofluorescence to study EI24 expression, localization, and function. Its specificity for the N-terminal region ensures accurate detection of full-length EI24. distinguishing it from potential degradation products or splice variants. Studies employing this antibody have shed light on EI24's involvement in stress adaptation, cancer progression, and metabolic diseases. Researchers value it as a tool to explore EI24's dual roles in pro-survival and pro-death pathways, particularly in contexts like chemotherapeutic response, neurodegeneration, and ER stress-related pathologies.
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