| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neural cell adhesion molecule 2, N-CAM-2, NCAM-2, NCAM2, NCAM21 |
| Entrez GeneID | 4685 |
| WB Predicted band size | 93.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This NCAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 620-649 amino acids from the Central region of human NCAM2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇与NCAM2抗体相关的文献摘要信息(虚构示例，实际文献需通过学术数据库检索)：
---
1. **文献名称**: *"NCAM2 regulates dendritic spine formation through interactions with the actin cytoskeleton"*
**作者**: Sytnyk V. et al.
**摘要**: 研究利用NCAM2特异性抗体进行免疫荧光定位，发现NCAM2通过调控肌动蛋白动力学促进树突棘形成，对突触可塑性具有重要作用。
---
2. **文献名称**: *"Altered NCAM2 expression in Alzheimer’s disease brain correlates with synaptic pathology"*
**作者**: Schneider A. et al.
**摘要**: 通过Western blot和免疫组化分析AD患者脑组织，发现NCAM2蛋白水平显著降低，提示其可能作为神经退行性疾病的潜在生物标志物。
---
3. **文献名称**: *"NCAM2 mediates cancer cell migration via modulation of focal adhesion signaling"*
**作者**: Leshchynska I. et al.
**摘要**: 使用NCAM2抗体阻断实验揭示其在癌细胞迁移中的作用，表明NCAM2通过整合素信号通路影响肿瘤侵袭性。
---
4. **文献名称**: *"Developmental expression of NCAM2 in the murine hippocampus and its role in memory consolidation"*
**作者**: Bukalo O. et al.
**摘要**: 研究通过NCAM2敲除小鼠模型及抗体标记，证明NCAM2在早期海马发育及长期记忆形成中不可或缺。
---
**提示**：实际文献建议通过PubMed或Google Scholar搜索关键词“NCAM2 antibody”或“NCAM2 function”，筛选近5年高被引论文获取准确信息。
**Background of NCAM2 Antibody**
Neural Cell Adhesion Molecule 2 (NCAM2), also known as OCAM or RNCAM, is a member of the immunoglobulin superfamily of cell adhesion molecules (CAMs). It plays critical roles in neural development, synaptic plasticity, and cell-cell interactions by mediating homophilic and heterophilic adhesion. NCAM2 is structurally characterized by extracellular immunoglobulin-like domains, fibronectin type III repeats, and a glycosylphosphatidylinositol (GPI) anchor or transmembrane domain, depending on splice variants.
NCAM2 antibodies are research tools designed to detect and study the expression, localization, and function of NCAM2 in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate NCAM2's involvement in neurodevelopmental processes, including axon guidance, neurite outgrowth, and neural circuit formation. Dysregulation of NCAM2 has been linked to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia, as well as neurodegenerative conditions like Alzheimer’s disease.
Recent studies also highlight NCAM2's potential role in cancer progression, particularly in modulating cell migration and metastasis. Antibodies targeting NCAM2 enable researchers to explore its mechanistic contributions to disease pathways, offering insights for therapeutic targeting. Due to its tissue-specific expression and functional diversity, NCAM2 remains a key focus in neuroscience and oncology research, with antibodies serving as essential reagents to unravel its complex biology.
×
