Rabbit Polyclonal SH3D20 Antibody

The SH3D20 antibody is designed to target the SH3 domain-containing protein 20 (SH3D20), a relatively understudied protein encoded by the *SH3D20* gene (also known as *C9orf89* or *SH3P20*). SH3D20 contains a conserved Src homology 3 (SH3) domain, a modular protein-interaction module that typically binds proline-rich motifs in partner proteins, suggesting its potential role in mediating protein-protein interactions critical for cellular signaling or trafficking processes. Though its precise biological function remains unclear, SH3D20 has been implicated in membrane dynamics, cell migration, and proliferation, with studies linking it to endoplasmic reticulum (ER) and Golgi apparatus localization. Emerging evidence associates SH3D20 with cancer progression, including hepatocellular carcinoma, breast cancer, and glioma, where altered expression levels correlate with tumor aggressiveness or patient prognosis. The SH3D20 antibody is widely utilized in research to detect endogenous SH3D20 protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its application extends to exploring SH3D20's role in disease mechanisms, particularly in oncogenesis and neurodegenerative disorders. However, due to limited functional characterization, studies often employ SH3D20 antibodies in conjunction with knockdown/knockout models to validate specificity and elucidate its molecular pathways. Further research is needed to fully unravel SH3D20's physiological and pathological significance.