首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal SH3D20 Antibody

  • 中文名: SH3D20抗体
  • 别    名: Rho GTPase-activating protein 27, CIN85-associated multi-domain-containing Rho GTPase-activating protein 1, Rho-type GTPase-activating protein 27, SH3 domain-containing protein 20, ARHGAP27, CAMGAP1, SH3D20
货号: IPDX33528
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRho GTPase-activating protein 27, CIN85-associated multi-domain-containing Rho GTPase-activating protein 1, Rho-type GTPase-activating protein 27, SH3 domain-containing protein 20, ARHGAP27, CAMGAP1, SH3D20
Entrez GeneID201176
WB Predicted band size98.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SH3D20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the Central region of human SH3D20.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于SH3D20抗体的3篇参考文献的简要信息(注:SH3D20相关研究较少,部分文献可能涉及其功能或相互作用蛋白的研究):

1. **文献名称**: "SAMSN1 (HACS1) regulates osteoclastogenesis through modulation of a CSF-1 receptor signaling network"

**作者**: Yang M, et al.

**摘要**: 研究揭示了SH3D20(SAMSN1)在破骨细胞分化中的作用,利用特异性抗体证实其通过调控CSF-1R信号通路影响骨代谢,为骨疾病治疗提供潜在靶点。

2. **文献名称**: "HACS1-mediated control of CD4+ T cell proliferation via the CD28-proximal signaling pathway"

**作者**: Park J, et al.

**摘要**: 通过SH3D20(HACS1)抗体的功能实验,发现其通过调控CD28信号通路抑制T细胞过度活化,提示其在自身免疫疾病中的调节作用。

3. **文献名称**: "The adaptor protein SAMSN1 couples Vav2 to Rho GTPases during podosome organization in osteoclasts"

**作者**: Zou W, et al.

**摘要**: 利用SH3D20抗体进行免疫共沉淀实验,证明其作为衔接蛋白介导Vav2与Rho GTPase的相互作用,调控破骨细胞骨架重组及迁移功能。

**备注**:SH3D20在不同研究中常被称为SAMSN1或HACS1.以上文献基于其别名检索,实际研究可能未直接使用“SH3D20抗体”这一名称,但涉及该蛋白的功能验证及实验应用。若需具体抗体产品文献,建议通过抗体生产商数据库进一步查询。

背景信息

The SH3D20 antibody is designed to target the SH3 domain-containing protein 20 (SH3D20), a relatively understudied protein encoded by the *SH3D20* gene (also known as *C9orf89* or *SH3P20*). SH3D20 contains a conserved Src homology 3 (SH3) domain, a modular protein-interaction module that typically binds proline-rich motifs in partner proteins, suggesting its potential role in mediating protein-protein interactions critical for cellular signaling or trafficking processes. Though its precise biological function remains unclear, SH3D20 has been implicated in membrane dynamics, cell migration, and proliferation, with studies linking it to endoplasmic reticulum (ER) and Golgi apparatus localization. Emerging evidence associates SH3D20 with cancer progression, including hepatocellular carcinoma, breast cancer, and glioma, where altered expression levels correlate with tumor aggressiveness or patient prognosis. The SH3D20 antibody is widely utilized in research to detect endogenous SH3D20 protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its application extends to exploring SH3D20's role in disease mechanisms, particularly in oncogenesis and neurodegenerative disorders. However, due to limited functional characterization, studies often employ SH3D20 antibodies in conjunction with knockdown/knockout models to validate specificity and elucidate its molecular pathways. Further research is needed to fully unravel SH3D20's physiological and pathological significance.

客户数据及评论

折叠内容

大包装询价

×