| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MRP; ABCC; GS-X; MRP1; ABC29 |
| WB Predicted band size | 172 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ABCC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HLA-DQA1 (N-term)抗体的模拟参考文献示例(请注意，以下内容为假设性概括，实际文献需通过学术数据库检索确认)：
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1. **"Development of a Novel Monoclonal Antibody Targeting the N-terminal Epitope of HLA-DQA1 for Immunohistochemical Applications"**
*作者：Lee et al. (2018)*
**摘要**：本研究报道了一种特异性识别HLA-DQA1蛋白N端表位的单克隆抗体的开发与验证。该抗体在Western blot和免疫组化中表现出高特异性，可用于检测组织样本中HLA-DQA1的表达水平，为研究其在自身免疫疾病中的分布提供了工具。
2. **"HLA-DQA1 Allelic Variation and Antibody Reactivity in Celiac Disease Pathogenesis"**
*作者：Garcia et al. (2015)*
**摘要**：通过使用针对HLA-DQA1 N端的多克隆抗体，研究者分析了乳糜泻患者中HLA-DQA1蛋白的构象变化与疾病相关性，揭示了特定等位基因的N端结构域在抗原呈递中的关键作用。
3. **"Structural Characterization of HLA-DQA1 Using Domain-Specific Antibodies"**
*作者：Zhang et al. (2020)*
**摘要**：该研究利用N端和C端特异性抗体，通过冷冻电镜技术解析了HLA-DQA1的分子构象，证实N端区域在二聚体形成中的重要性，为理解MHC II类分子的功能机制提供了结构学依据。
4. **"Autoantibodies Against HLA-DQA1 in Type 1 Diabetes: A Comparative Study"**
*作者：Müller et al. (2019)*
**摘要**：研究使用N端定向抗体检测1型糖尿病患者血清中的HLA-DQA1自身抗体，发现其与疾病进展显著相关，提示该表位可能作为早期诊断的生物标志物。
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建议通过PubMed或Google Scholar以关键词“HLA-DQA1 antibody N-terminal”或“HLA-DQA1 epitope mapping”检索最新文献以获取真实数据。
The HLA-DQA1 (N-term) antibody targets the N-terminal region of the HLA-DQA1 protein, a key component of the human leukocyte antigen (HLA) class II system. HLA class II molecules, encoded by genes in the MHC (major histocompatibility complex) region, are critical for adaptive immunity, presenting exogenous antigens to CD4+ T cells. HLA-DQA1 is a polymorphic gene that encodes the alpha chain of the HLA-DQ heterodimer, which pairs with the beta chain (encoded by HLA-DQB1) to form functional cell surface receptors. Variations in HLA-DQA1 are strongly linked to autoimmune diseases, including celiac disease, type 1 diabetes, and rheumatoid arthritis, due to their role in shaping antigen-binding specificity and immune response regulation.
Antibodies against the N-terminal region of HLA-DQA1 are valuable tools for studying protein expression, localization, and function in immunological research. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess HLA-DQ complex formation, tissue distribution, or disease-associated expression patterns. Such antibodies are often validated for specificity using knockout cell lines or recombinant proteins, ensuring minimal cross-reactivity with other HLA class II alpha chains (e.g., HLA-DRA, HLA-DPA1). Research applications include investigating HLA-DQ's role in autoimmune mechanisms, antigen presentation pathways, or genetic susceptibility studies. Commercial antibodies are typically raised in hosts like rabbits or mice using synthetic peptides or recombinant proteins as immunogens, with validation data supporting their utility in both native and denatured protein contexts.
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