Rabbit Polyclonal VEGF3(N-term) Antibody

The VEGF3 (N-term) antibody is a specialized tool used to detect Vascular Endothelial Growth Factor Receptor 3 (VEGFR3), also known as FLT4. a tyrosine kinase receptor critical in lymphatic and vascular biology. VEGFR3 is primarily expressed in lymphatic endothelial cells and regulates lymphangiogenesis (lymphatic vessel formation) and vascular maintenance. It binds ligands VEGF-C and VEGF-D, triggering signaling pathways that promote cell survival, proliferation, and migration. Dysregulation of VEGFR3 is linked to pathologies like lymphedema, tumor metastasis, and inflammatory diseases. The antibody targets the N-terminal extracellular domain of VEGFR3. a region involved in ligand binding and receptor activation. Researchers use this antibody in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study VEGFR3 expression, localization, and function in tissues or cultured cells. Its specificity for the N-terminal region helps distinguish VEGFR3 from other VEGF receptors (VEGFR1. VEGFR2) and ensures accurate detection in experimental models. Studies leveraging this antibody have advanced our understanding of lymphatic system disorders and cancer biology, particularly mechanisms driving tumor-associated lymphangiogenesis and metastatic spread via lymphatic vessels.