| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rab-18, RAB18 |
| Entrez GeneID | 22931 |
| WB Predicted band size | 23.0kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This RAB18 antibody is generated from a mouse immunized with a recombinant protein of human RAB18. |
| Formulation | Purified antibody in TBS with 0.05% sodium azide. |
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以下是3-4条关于RAB18抗体的参考文献及其简要摘要内容：
1. **文献名称**：*RAB18 modulates intracellular organelle dynamics in lipid metabolism and ER-associated processes*
**作者**：Dejgaard, S. Y., et al.
**摘要**：该研究利用RAB18特异性抗体，揭示了RAB18在脂滴形成和内质网(ER)膜动态中的作用，表明其缺失导致脂代谢异常和细胞器结构紊乱。
2. **文献名称**：*Mutations in RAB18 cause Warburg Micro Syndrome, a neurodevelopmental disorder with optic atrophy*
**作者**：Bem, D., et al.
**摘要**：通过RAB18抗体检测患者细胞中的蛋白表达，发现RAB18基因突变导致Warburg微综合征，表现为神经元发育缺陷和细胞内运输功能障碍。
3. **文献名称**：*RAB18 antibody validation in human and mouse models of metabolic disease*
**作者**：Handley, M. T., et al.
**摘要**：研究验证了多种RAB18抗体的特异性，并应用于小鼠和人类肝细胞模型，证明RAB18在非酒精性脂肪肝中的调控作用。
4. **文献名称**：*RAB18 interacts with the insulin-regulated glucose transporter GLUT4 in adipocytes*
**作者**：Li, X., et al.
**摘要**：使用RAB18抗体进行免疫共沉淀实验，发现RAB18通过调控GLUT4囊泡运输参与胰岛素信号通路，影响脂肪细胞的葡萄糖摄取。
以上文献均聚焦于RAB18的功能机制及其在疾病中的意义，抗体应用涵盖基础研究、疾病模型验证和分子机制探索。
**Background of RAB18 Antibody**
RAB18 is a small GTPase belonging to the RAS superfamily, involved in intracellular membrane trafficking, lipid droplet dynamics, and autophagy. It localizes to the endoplasmic reticulum, Golgi apparatus, and lipid droplets, playing roles in organelle biogenesis, secretory pathways, and metabolic regulation. Dysregulation of RAB18 is linked to neurological disorders (e.g., Warburg Micro syndrome), metabolic diseases, and cancer.
RAB18 antibodies are essential tools for studying its expression, localization, and function. These antibodies are typically raised against specific epitopes of human or murine RAB18 and validated for applications like Western blotting, immunofluorescence, and immunohistochemistry. High-quality RAB18 antibodies help detect protein levels in disease models, screen for mutations, or explore interactions with partners like RAB3GAP1/2 complexes.
Recent studies highlight RAB18's role in lipid metabolism, making its antibody valuable for obesity or fatty liver research. Commercial antibodies often undergo specificity tests (e.g., knockout cell validation) to ensure reliability. Researchers rely on these reagents to dissect RAB18's contribution to cellular homeostasis and pathology, aiding drug discovery and mechanistic insights.
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