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Rabbit Polyclonal hsp90a.1 Antibody

  • 中文名: hsp90a.1抗体
  • 别    名: Heat shock protein HSP 90-alpha 1, hsp90a1, hsp90, hsp90a, hsp90aa1
货号: IPDX33514
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 zebrafish
IF 咨询技术 zebrafish
IHC 咨询技术 zebrafish
ICC 技术咨询 zebrafish
FCM 咨询技术 zebrafish
Elisa 咨询技术 zebrafish

产品详情

AliasesHeat shock protein HSP 90-alpha 1, hsp90a1, hsp90, hsp90a, hsp90aa1
Entrez GeneID30591
WB Predicted band size83.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivityzebrafish
ImmunogenThis hsp90a.1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 229-263 amino acids from the Central region of human (DANRE) hsp90a.1.

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参考文献

以下是关于HSP90α(HSP90AA1)抗体的参考文献示例(内容基于公开研究整理,建议核对原文准确性):

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1. **文献名称**: *Plasma HSP90α as a Novel Biomarker for Diagnosis of Liver Cancer*

**作者**: Wu J, et al.

**摘要**: 该研究开发了一种特异性识别HSP90α的单克隆抗体,用于检测肝癌患者血浆中的HSP90α水平,证明其作为非侵入性诊断标志物的潜力,敏感性显著高于传统标志物AFP。

2. **文献名称**: *HSP90α Inhibition Depletes Oncogenic Client Proteins in Melanoma*

**作者**: Neckers L, et al.

**摘要**: 通过HSP90α抗体(如C1C8克隆)验证HSP90抑制剂(如17-AAG)对黑色素瘤的作用,发现抑制HSP90后,下游致癌蛋白(如BRAF、AKT)表达显著降低,提示治疗潜力。

3. **文献名称**: *Extracellular HSP90α Promotes Breast Cancer Metastasis via MMP2 Activation*

**作者**: Eustace BK, et al.

**摘要**: 使用HSP90α特异性抗体阻断细胞外HSP90α的功能,发现其通过激活MMP2促进乳腺癌侵袭转移,提示靶向细胞外HSP90α的治疗策略。

4. **文献名称**: *Differential Subcellular Localization of HSP90 Isoforms in Neurons*

**作者**: Sreedhar AS, et al.

**摘要**: 对比HSP90α与HSP90β抗体染色结果,揭示HSP90α在神经元突触中的富集,可能与神经退行性疾病中错误折叠蛋白的调控相关。

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**注意**:以上内容为示例,实际文献需通过PubMed、Google Scholar等平台检索确认。建议使用关键词“HSP90AA1 antibody”、“HSP90α biomarker”或“HSP90 inhibitor”查找最新研究。

背景信息

The HSP90A.1 antibody targets the heat shock protein 90 alpha family class A member 1 (HSP90AA1), a cytosolic isoform of the HSP90 chaperone family. HSP90 proteins are essential molecular chaperones involved in stabilizing and activating client proteins, including signaling kinases, transcription factors, and steroid hormone receptors. They play critical roles in cellular stress response, protein folding, and cancer progression. The HSP90α isoform (encoded by HSP90AA1) is stress-inducible and often overexpressed in tumor cells, where it supports oncoprotein stability and promotes metastasis. Antibodies against HSP90A.1 are widely used to study its expression, subcellular localization, and interactions in both normal and pathological conditions. These tools help elucidate HSP90α's involvement in diseases like cancer, neurodegenerative disorders, and inflammatory conditions. Commercial HSP90A.1 antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and immunoprecipitation, with specificity confirmed through knockout controls. Research using this antibody has contributed to drug development efforts, as HSP90 inhibitors are explored for cancer therapy. However, challenges remain in distinguishing HSP90α from closely related isoforms like HSP90β in certain experimental setups, emphasizing the need for antibody validation in specific contexts.

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