Rabbit Polyclonal hsp90a.1 Antibody

The HSP90A.1 antibody targets the heat shock protein 90 alpha family class A member 1 (HSP90AA1), a cytosolic isoform of the HSP90 chaperone family. HSP90 proteins are essential molecular chaperones involved in stabilizing and activating client proteins, including signaling kinases, transcription factors, and steroid hormone receptors. They play critical roles in cellular stress response, protein folding, and cancer progression. The HSP90α isoform (encoded by HSP90AA1) is stress-inducible and often overexpressed in tumor cells, where it supports oncoprotein stability and promotes metastasis. Antibodies against HSP90A.1 are widely used to study its expression, subcellular localization, and interactions in both normal and pathological conditions. These tools help elucidate HSP90α's involvement in diseases like cancer, neurodegenerative disorders, and inflammatory conditions. Commercial HSP90A.1 antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and immunoprecipitation, with specificity confirmed through knockout controls. Research using this antibody has contributed to drug development efforts, as HSP90 inhibitors are explored for cancer therapy. However, challenges remain in distinguishing HSP90α from closely related isoforms like HSP90β in certain experimental setups, emphasizing the need for antibody validation in specific contexts.