| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | U3 small nucleolar RNA-associated protein 6 homolog, Hepatocellular carcinoma-associated antigen 66, Multiple hat domains protein, UTP6, C17orf40, HCA66, MHAT |
| Entrez GeneID | 55813 |
| WB Predicted band size | 70.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This UTP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human UTP6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于UTP6(N-term)抗体的3篇文献摘要示例(注：文献为假设性示例，实际引用需检索数据库如PubMed)：
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1. **标题**: *"UTP6 is essential for pre-rRNA processing and ribosome biogenesis in human cells"*
**作者**: García-Tuñón I, et al.
**摘要**: 研究通过生成针对UTP6 N端的多克隆抗体，验证其在HeLa细胞中的核仁定位，并证明UTP6缺失导致18S rRNA加工缺陷，强调其在小亚基形成中的关键作用。
2. **标题**: *"Characterization of the U3 snoRNP complex subunits in Arabidopsis using specific antibodies"*
**作者**: Wang L, et al.
**摘要**: 文中利用UTP6(N-term)抗体进行免疫沉淀和Western blot分析，揭示拟南芥中UTP6与U3 snoRNP其他组分的相互作用，及其在植物rRNA前体剪切中的功能。
3. **标题**: *"Antibody-based profiling of ribosome assembly factors in zebrafish development"*
**作者**: Chen R, et al.
**摘要**: 研究通过斑马鱼模型，使用UTP6 N端抗体进行免疫荧光染色，发现UTP6在胚胎早期神经发育阶段高表达，提示其与组织特异性核仁活动相关。
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**提示**：实际文献需通过学术数据库检索关键词(如“UTP6 antibody”、“ribosome biogenesis”)。商业抗体手册(如Sigma-Aldrich或Abcam产品页)也可能提供相关应用文献。
The UTP6 (N-term) antibody is a specialized tool used to detect the N-terminal region of UTP6 (Utp6 protein), a critical component of the small subunit (SSU) processome involved in ribosomal RNA (rRNA) biogenesis. UTP6. also known as Cirhin or C1D, is part of the UTP complex, which facilitates 18S rRNA maturation within the nucleolus. This antibody specifically targets epitopes near the N-terminus of UTP6. enabling researchers to study its expression, localization, and interactions in cellular processes.
UTP6 plays a vital role in ribosome assembly, linking rRNA transcription to pre-rRNA processing. Dysregulation of UTP6 or its associated complexes has been implicated in developmental disorders and cancers, such as North American Indian childhood cirrhosis (NAIC) due to CIRH1A (UTP6) mutations. The UTP6 (N-term) antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate these mechanisms. Its specificity helps distinguish UTP6 from other UTP proteins, aiding in functional studies of nucleolar organization and ribosomopathies. Validated in multiple species, this antibody is essential for probing rRNA biogenesis pathways and their disease connections.
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