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Rabbit Polyclonal PICALM Antibody

  • 中文名: PICALM抗体
  • 别    名: Phosphatidylinositol-binding clathrin assembly protein, Clathrin assembly lymphoid myeloid leukemia protein, PICALM, CALM
货号: IPDX33508
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPhosphatidylinositol-binding clathrin assembly protein, Clathrin assembly lymphoid myeloid leukemia protein, PICALM, CALM
Entrez GeneID8301
WB Predicted band size70.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis PICALM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 512-543 amino acids from human PICALM.

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参考文献

以下是3篇关于PICALM抗体的参考文献概览(文献标题、作者及摘要简述):

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1. **"PICALM modulates autophagy activity and tau accumulation in Alzheimer's disease models"**

*作者:Moreau K. et al.*

摘要:研究利用PICALM特异性抗体分析转基因小鼠脑组织,发现PICALM通过调控自噬通路影响tau蛋白聚集,提示其在阿尔茨海默病病理中的关键作用。

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2. **"PICALM regulates clathrin-coated vesicle formation in cancer cell invasion"**

*作者:Chen Y. et al.*

摘要:通过PICALM抗体抑制实验,揭示PICALM在肿瘤细胞中调控网格蛋白包被囊泡形成,促进癌细胞迁移和侵袭,为靶向治疗提供新思路。

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3. **"Autoantibodies against PICALM in autoimmune encephalitis: Clinical and immunological characterization"**

*作者:Lai M. et al.*

摘要:首次报道PICALM自身抗体在自身免疫性脑炎患者血清中的存在,结合抗体滴度分析阐明其与认知障碍的潜在关联,拓展了神经免疫疾病标志物研究。

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注:以上文献为示例,实际引用时需根据具体研究补充完整信息(期刊、年份、DOI等)。如需真实文献,建议在PubMed或Web of Science中以“PICALM antibody”为关键词检索近年高影响力论文。

背景信息

The PICALM (Phosphatidylinositol Binding Clathrin Assembly Protein) antibody is a tool used to study the PICALM protein, a key player in clathrin-mediated endocytosis. PICALM, also known as CALM, facilitates vesicle formation by linking clathrin to phosphatidylinositol-rich membranes, influencing cellular processes like receptor internalization, membrane trafficking, and synaptic vesicle recycling. It is encoded by the *PICALM* gene on human chromosome 11 and has garnered significant attention due to its association with Alzheimer’s disease (AD). Genome-wide association studies (GWAS) identified *PICALM* as a risk gene for late-onset AD, potentially impacting amyloid-β processing and tau pathology. Additionally, PICALM is implicated in cancers, particularly acute leukemias, where chromosomal translocations involving *PICALM* (e.g., *PICALM-MLLT10* fusion) drive oncogenesis. Antibodies targeting PICALM are widely used in research to investigate its expression, localization, and interactions in normal and diseased tissues. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding studies on PICALM’s role in neurodegeneration, cancer biology, and cellular trafficking pathways. Recent work also explores its involvement in autophagy and iron metabolism, highlighting its multifaceted cellular functions. The PICALM antibody thus serves as a critical reagent for unraveling molecular mechanisms in AD, oncology, and basic cell biology research.

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