Rabbit Polyclonal PICALM Antibody

The PICALM (Phosphatidylinositol Binding Clathrin Assembly Protein) antibody is a tool used to study the PICALM protein, a key player in clathrin-mediated endocytosis. PICALM, also known as CALM, facilitates vesicle formation by linking clathrin to phosphatidylinositol-rich membranes, influencing cellular processes like receptor internalization, membrane trafficking, and synaptic vesicle recycling. It is encoded by the *PICALM* gene on human chromosome 11 and has garnered significant attention due to its association with Alzheimer’s disease (AD). Genome-wide association studies (GWAS) identified *PICALM* as a risk gene for late-onset AD, potentially impacting amyloid-β processing and tau pathology. Additionally, PICALM is implicated in cancers, particularly acute leukemias, where chromosomal translocations involving *PICALM* (e.g., *PICALM-MLLT10* fusion) drive oncogenesis. Antibodies targeting PICALM are widely used in research to investigate its expression, localization, and interactions in normal and diseased tissues. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding studies on PICALM’s role in neurodegeneration, cancer biology, and cellular trafficking pathways. Recent work also explores its involvement in autophagy and iron metabolism, highlighting its multifaceted cellular functions. The PICALM antibody thus serves as a critical reagent for unraveling molecular mechanisms in AD, oncology, and basic cell biology research.