WB | 1/2000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | Phosphatidylinositol-binding clathrin assembly protein, Clathrin assembly lymphoid myeloid leukemia protein, PICALM, CALM |
Entrez GeneID | 8301 |
WB Predicted band size | 70.8kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | This PICALM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 512-543 amino acids from human PICALM. |
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以下是3篇关于PICALM抗体的参考文献概览(文献标题、作者及摘要简述):
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1. **"PICALM modulates autophagy activity and tau accumulation in Alzheimer's disease models"**
*作者:Moreau K. et al.*
摘要:研究利用PICALM特异性抗体分析转基因小鼠脑组织,发现PICALM通过调控自噬通路影响tau蛋白聚集,提示其在阿尔茨海默病病理中的关键作用。
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2. **"PICALM regulates clathrin-coated vesicle formation in cancer cell invasion"**
*作者:Chen Y. et al.*
摘要:通过PICALM抗体抑制实验,揭示PICALM在肿瘤细胞中调控网格蛋白包被囊泡形成,促进癌细胞迁移和侵袭,为靶向治疗提供新思路。
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3. **"Autoantibodies against PICALM in autoimmune encephalitis: Clinical and immunological characterization"**
*作者:Lai M. et al.*
摘要:首次报道PICALM自身抗体在自身免疫性脑炎患者血清中的存在,结合抗体滴度分析阐明其与认知障碍的潜在关联,拓展了神经免疫疾病标志物研究。
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注:以上文献为示例,实际引用时需根据具体研究补充完整信息(期刊、年份、DOI等)。如需真实文献,建议在PubMed或Web of Science中以“PICALM antibody”为关键词检索近年高影响力论文。
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